Quantitative assessment of diffuse optical tomography sensitivity to the cerebral cortex using a whole-head probe.
Quantitative assessment of diffuse optical tomography sensitivity to the cerebral cortex using a whole-head probe.
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DOI：
10.1088/0031-9155/57/10/2857
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发表时间：
2012-05-21
影响因子：
3.5
通讯作者：
Diamond SG
中科院分区：
文献类型：
--
作者：
Perdue KL;Fang Q;Diamond SG
我们量化的变化，在弥漫性光学断层扫描（DOT）的敏感性在8个年轻的成年受试者的皮质表面。我们使用10/5脑电图系统作为我们的全头光学高密度探头设计的基础。对比度噪声比（CNR）与高于CNR=0 dB阈值的皮质百分比一起沿着计算。我们还量化了包括脉管系统对正演模型的影响，并列出了我们的假设，使我们能够估计光在头部的穿透深度。我们表明，使用10/5系统的光学探头设计允许测量平均37%的皮质表面，在可见光区的平均CNR为5.5 dB。某些解剖区域，如外侧枕叶皮质，有一个非常高的百分比高于CNR阈值，而其他区域，如扣带皮质是不可测量的。血管系统阻断了超过1%的皮层的光学敏感性。皮质覆盖率与颅内体积和相对脑脊液体积正相关，与相对头皮体积和颅骨体积负相关。这些贡献使实验人员能够了解受试者群体中的解剖学变化如何影响DOT或功能性近红外光谱测量。
We quantify the variability in diffuse optical tomography (DOT) sensitivity over the cortical surface in eight young adult subjects. We use the 10/5 electroencephalography system as a basis for our whole-head optical high-density probe design. The contrast-to-noise ratio (CNR) is calculated along with the percentage of the cortex that is above a CNR=0 dB threshold. We also quantify the effect of including vasculature on the forward model and list our assumptions that allow us to estimate light penetration depth in the head. We show that using the 10/5 system for optical probe design allows for measurement of 37% of the cortical surface on average, with a mean CNR in the visible region of 5.5 dB. Certain anatomical regions, such as the lateral occipital cortex, had a very high percentage above the CNR threshold, while other regions such as the cingulate cortex were not measurable. Vasculature blocked optical sensitivity over 1% of the cortex. Cortical coverage was positively correlated with intracranial volume and relative cerebrospinal fluid volume, and negatively correlated with relative scalp volume and skull volume. These contributions allow experimenters to understand how anatomical variation in a subject population may impact DOT or functional near-infrared spectroscopy measurements.
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