Photoacoustic Molecular Imaging: From Multiscale Biomedical Applications Towards Early-Stage Theranostics.

Photoacoustic Molecular Imaging: From Multiscale Biomedical Applications Towards Early-Stage Theranostics.
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光声分子成像:从多尺度生物医学应用到早期治疗诊断学。

DOI:
10.1016/j.tibtech.2016.02.001
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发表时间:
2016-05
影响因子:
17.3
通讯作者:
Chen X
Chen X
中科院分区:
工程技术1区
文献类型:
--
作者:
Liu Y;Nie L;Chen X

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近年来,光声成像(PAI)引领了生物技术观察的新时代,促进了对生物基本机制和临床转化应用的探索,引起了人们的极大关注。PAI通过将激光转化为超声发射,在单一模态中结合了丰富的光学对比度、高的超声空间分辨率和较深的穿透深度。这种进化技术具有高灵敏度和特异性,可以实现从细胞到器官、解剖到功能、分子到代谢的多尺度和多对比度可视化。本文介绍了PAI的最新发展和应用。并对其临床应用前景进行了展望。总的来说,PAI在推动生物医学应用于早期治疗方面有着巨大的希望。
Photoacoustic imaging (PAI) has ushered in a new era of observing biotechnology and facilitated the exploration of fundamental biological mechanisms and clinical translational applications, which has attracted tremendous attention in recent years. By converting laser into ultrasound emission, PAI combines rich optical contrast, high ultrasonic spatial resolution, and deep penetration depth in a single modality. This evolutional technique enables multiscale and multicontrast visualization from cells to organs, anatomy to function, and molecules to metabolism with high sensitivity and specificity. The state-of-the-art developments and applications of PAI are described in this review. Future prospects to clinical use are also highlighted. Collectively, PAI holds great promise to drive biomedical applications towards early-stage theranostics.
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