Clinicopathologic features of epithelial ovarian carcinoma in younger vs. older patients: analysis in Japanese women.
Clinicopathologic features of epithelial ovarian carcinoma in younger vs. older patients: analysis in Japanese women.
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DOI：
10.3802/jgo.2014.25.2.118
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发表时间：
2014-04
影响因子：
3.9
通讯作者：
Kikkawa F
中科院分区：
文献类型：
--
作者：
Yoshikawa N;Kajiyama H;Mizuno M;Shibata K;Kawai M;Nagasaka T;Kikkawa F
本研究的目的是阐明日本年轻患者与老年患者的卵巢上皮癌（EOC）的临床特征。我们收集了东海卵巢肿瘤研究组在多个机构接受治疗的1,562例EOC患者的数据，并对其进行了回顾性分析。所有患者分为两组：A组（≤40岁）和B组（>40岁）。分析数据以评估预后因素和各组特征的分布。对患者进行单变量和多变量分析，以评估总生存期（OS）。中位随访时间为45.1个月（范围：1 - 257个月）。与B组相比，A组患者的I期疾病（分别为67.3%和42.6%; p<0.001）和粘液型（分别为36.7%和13.5%; p<0.001）发生率显著较高。两组之间的OS存在显著差异（p=0.013）。然而，根据分期分层后，两组之间的OS无显著差异（A组与B组：I期，p=0.533; II-IV期，p=0.407）。多变量分析显示，年龄较小不是OS的独立预后因素。根据我们的数据，年轻患者的临床特征与老年患者不同，特别是在疾病分期和病理分布方面;然而，即使根据分期分层，他们也显示出相似的长期预后。
The purpose of this study was to clarify the clinical features of epithelial ovarian carcinoma (EOC) in younger vs. older patients in Japan. We collected data on 1,562 patients with EOC treated at multiple institutions in the Tokai Ovarian Tumor Study Group, and analyzed them retrospectively. All patients were divided into 2 groups: group A (≤40 years old) and group B (>40 years old). The data were analyzed to evaluate prognostic factors and the distribution of features in each group. Patients were subjected to univariate and multivariate analyses to evaluate overall survival (OS). The median follow-up time was 45.1 months (range, 1 to 257 months). Patients in group A had a significantly higher rate of stage I disease (67.3% vs. 42.6%, respectively; p<0.001) and the mucinous type (36.7% vs. 13.5%, respectively; p<0.001) than those in group B. There was a significant difference of OS between the 2 groups (p=0.013). However, upon stratification according to the stage, there were no significant differences in the OS between the 2 groups (group A vs. B: stage I, p=0.533; stage II-IV, p=0.407). Multivariate analysis revealed that younger age was not an independent prognostic factor for OS. On the basis of our data, younger patients had a different clinical profile than older patients, particularly regarding the stage of the disease and pathological distribution; however, they showed a similar long-term prognosis, even upon stratification according to the stage.
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影响因子：
3.8
作者：
Kajiyama, H.;Shibata, K.;Kikkawa, F.
通讯作者：
Kikkawa, F.
影响因子：
4.7
作者：
Schilder, JM;Thompson, AM;van Nagell, J
通讯作者：
van Nagell, J
影响因子：
50.5
作者：
Fruscio, R.;Corso, S.;Colombo, N.
通讯作者：
Colombo, N.
影响因子：
4.7
作者：
Kajiyama, Hiroaki;Shibata, Kiyosumi;Kikkawa, Fumitaka
通讯作者：
Kikkawa, Fumitaka
与接受根治性手术的年轻女性接受卵巢癌的长期生存。
影响因子：
8.8
作者：
Kajiyama, H.;Shibata, K.;Mizuno, M.;Umezu, T.;Suzuki, S.;Nawa, A.;Kawai, M.;Nagasaka, T.;Kikkawa, F.
通讯作者：
Kikkawa, F.