Neural mechanisms linked to treatment outcomes and recovery in substance-related and addictive disorders.

Neural mechanisms linked to treatment outcomes and recovery in substance-related and addictive disorders.
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与物质相关和成瘾障碍的治疗结果和康复相关的神经机制。

DOI:
10.1080/19585969.2023.2242359
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发表时间:
2023-12
影响因子:
8.3
通讯作者:
--
中科院分区:
医学2区
文献类型:
--
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本综述的重点是潜在的神经机制恢复精神疾病的特点是受损的冲动控制,特别是物质使用障碍,赌博障碍,网络游戏障碍。针对这些成瘾的现有治疗(包括药理学和心理学)可能会影响大脑过程,这些已经在神经影像学研究中进行了评估。将考虑药物激发和短期干预给药的治疗效用。成瘾的主要模式(例如,双重过程,奖赏缺乏综合征)将在现有数据的背景下考虑。此外,先进的分析方法(例如,机器学习方法)将在指导治疗开发工作方面予以考虑。因此,这篇叙述性综述旨在为成瘾性疾病的治疗开发提供方向。
The present review focuses on potential neural mechanisms underlying recovery from psychiatric conditions characterised by impaired impulse control, specifically substance use disorders, gambling disorder, and internet gaming disorder. Existing treatments (both pharmacological and psychological) for these addictions may impact brain processes, and these have been evaluated in neuroimaging studies. Medication challenge and short-term intervention administration will be considered with respect to treatment utility. Main models of addiction (e.g., dual process, reward deficiency syndrome) will be considered in the context of extant data. Additionally, advanced analytic approaches (e.g., machine-learning approaches) will be considered with respect to guiding treatment development efforts. Thus, this narrative review aims to provide directions for treatment development for addictive disorders.
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