Reorganization of corticospinal tract fibers after spinal cord injury in adult macaques.
Reorganization of corticospinal tract fibers after spinal cord injury in adult macaques.
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DOI：
10.1038/srep11986
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发表时间：
2015-07-01
影响因子：
4.6
通讯作者：
Takada M
中科院分区：
文献类型：
--
作者：
Nakagawa H;Ninomiya T;Yamashita T;Takada M
先前的研究表明，脊髓损伤（SCI）后皮质脊髓束（CST）纤维的萌发有助于运动功能的恢复。然而，通过 CST 纤维发芽实现功能恢复的神经解剖学机制仍不清楚。在这里，我们研究了成年猕猴 SCI 后病变部位以下 CST 纤维的重组模式。在 C7 和 C8 段之间的水平进行单侧损伤。通过伸手/抓握任务评估手动灵活性的自发恢复程度。 SCI后受损的灵巧手部运动逐渐恢复。当使用生物素化葡聚糖胺进行顺行束追踪以识别出芽 CST 纤维的椎管内神经支配时，发现 CST 纤维的层状分布发生了变化。发芽的 CST 纤维优先延伸到脊髓运动神经元池所在的第九层，直接支配运动神经元。相反，很少（如果有的话）CST 纤维分布在背板中。目前的结果表明，猕猴 SCI 后病变部位下方的 CST 纤维随着灵巧手动运动的恢复而重组。
Previous studies have shown that sprouting of corticospinal tract (CST) fibers after spinal cord injury (SCI) contributes to recovery of motor functions. However, the neuroanatomical mechanism underlying the functional recovery through sprouting CST fibers remains unclear. Here we investigated the pattern of reorganization of CST fibers below the lesion site after SCI in adult macaques. Unilateral lesions were made at the level between the C7 and the C8 segment. The extent of spontaneous recovery of manual dexterity was assessed with a reaching/grasping task. The impaired dexterous manual movements were gradually recovered after SCI. When anterograde tract tracing with biotinylated dextran amine was performed to identify the intraspinal reinnervation of sprouting CST fibers, it was found that the laminar distribution of CST fibers was changed. The sprouting CST fibers extended preferentially into lamia IX where the spinal motor neuron pool was located, to innervate the motor neurons directly. Instead, few, if any, CST fibers were distributed in the dorsal laminae. The present results indicate that CST fibers below the lesion site after SCI in macaques are reorganized in conjunction with the recovery of dexterous manual movements.
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影响因子：
14.5
作者：
Vavrek, R.;Girgis, J.;Fouad, K.
通讯作者：
Fouad, K.
抗Nogo-A抗体治疗促进成年灵长类单侧颈椎损伤后手灵巧度的恢复——行为数据的重新检查和扩展。
DOI：
10.1111/j.1460-9568.2009.06642.x
发表时间：
2009-03
期刊：
The European journal of neuroscience
影响因子：
--
作者：
Freund P;Schmidlin E;Wannier T;Bloch J;Mir A;Schwab ME;Rouiller EM
通讯作者：
Rouiller EM
影响因子：
2.5
作者：
Lacroix, S;Havton, LA;Tuszynski, MH
通讯作者：
Tuszynski, MH
影响因子：
56.9
作者：
Nishimura, Yukio;Onoe, Hirotaka;Isa, Tadashi
通讯作者：
Isa, Tadashi
影响因子：
3.4
作者：
Hoogewoud, Florence;Hamadjida, Adjia;Rouiller, Eric M.
通讯作者：
Rouiller, Eric M.