Dietary supplementation for female infertility: Recent advances in the nutritional therapy for premature ovarian insufficiency.
Dietary supplementation for female infertility: Recent advances in the nutritional therapy for premature ovarian insufficiency.
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DOI：
10.3389/fmicb.2022.1001209
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发表时间：
2022
影响因子：
5.2
通讯作者：
Du, Yanzhi
中科院分区：
文献类型：
--
作者：
Han, Qixin;Chen, Zi-Jiang;Du, Yanzhi
卵巢功能不全(POI)在生殖障碍中居首位，这些疾病可能会损害女性的多个功能系统，降低生活质量，并最终剥夺患者的生育能力。目前的激素替代疗法既不能改善妊娠，也不能降低全身并发症的发生率，可以部分缓解症状。营养膳食补充剂因其安全性、生物利用度和增进健康的功效而受到越来越多的关注。日常食物中的营养素由碳水化合物、脂肪和脂蛋白、蛋白质和多肽、维生素和含有植物雌激素的蔬菜或水果组成。这些都是功能性营养素，因为在更年期过程中具有增殖、抗炎、抗氧化和保护线粒体的潜力。除膳食营养外，微生物相关营养物质，包括益生菌、益生菌和组合合生菌，在支持发情周期、卵巢活力和调节其他重要生殖功能方面也显示出很大的潜力。本文将在动物和人体研究的基础上，讨论膳食和微生物营养素及其在活体中的作用和应用，从分子、细胞和组织水平评估可能的作用机制，并为延长女性患者生殖寿命的营养治疗提供见解。
Premature ovarian insufficiency (POI) ranks top in the reproductive disorders that may impair multiple functioning systems, reduce the quality of life and ultimately deprive patients of their fertility among women. Symptoms can be partially alleviated by present hormone replacement therapy that cannot improve conception or decrease occurrence rates of systemic complication. Nutritional dietary supplements are attracting more and more attention because of their safety, bioavailability, and efficacy for well-being. Nutrients in the daily food are composed of carbohydrates, fat and lipoprotein, protein and polypeptide, vitamins, and vegetable or fruits containing phytoestrogens. These are functional nutrients due to the proliferative, anti-inflammatory, anti-oxidant, and mitochondria-protective potential during the course of menopause. Apart from dietary nutrients, microbe-related nutritional substances, including probiotics, prebiotics and the combination-synbiotics, display high potential as well in supporting estrous cycle, ovarian viability and modulating other vital reproductive functions. The present review will discuss dietary and microbial nutrients and their roles and applications in the living body based upon animal or human research, evaluate possible effect mechanisms from molecular, cellular and tissue levels, and provide insights into nutritional therapy for prolonging reproductive lifespan in female patients.
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影响因子：
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