Neonatal outcomes after antenatal influenza immunization during the 2009 H1N1 influenza pandemic: impact on preterm birth, birth weight, and small for gestational age birth.
Neonatal outcomes after antenatal influenza immunization during the 2009 H1N1 influenza pandemic: impact on preterm birth, birth weight, and small for gestational age birth.
复制标题
DOI：
10.1093/cid/cit045
复制
发表时间：
2013-05
期刊：
影响因子：
--
通讯作者：
Omer SB
中科院分区：
文献类型：
--
作者：
Richards JL;Hansen C;Bredfeldt C;Bednarczyk RA;Steinhoff MC;Adjaye-Gbewonyo D;Ault K;Gallagher M;Orenstein W;Davis RL;Omer SB
在2009年甲型H1N1流感大流行期间，接种H1N1疫苗的母亲的婴儿早产的几率降低了38%，平均比未接种疫苗的母亲的婴儿重45.0 g。 背景：妊娠期流感感染与不良胎儿结局相关，如早产和小于胎龄儿（SGA）。 在流感流行期间，母亲接种流感疫苗可以预防这些不良的婴儿结局。 方法：我们对2009年甲型H1N1流感病毒流行期间凯萨医疗机构（KP）格鲁吉亚和大西洋中部各州（n = 3327）的活产婴儿进行了回顾性队列研究。 主要结局为妊娠晚期早产（27 - 36周）、出生体重、低出生体重（LBW，<2500 g）和SGA。 结果：327例（9.8%）早产，236例（7.4%）LBW，267例（8.4%）SGA。 在接种H1N1疫苗的母亲中（n = 1125），有86例（7.6%）早产、68例（6.4%）LBW和99例（9.3%）SGA分娩，平均出生体重为3308.5 g（95%置信区间[CI]，3276.6 - 3340.4）。在未接种疫苗的母亲（n = 1581）中，有191例（12.1%）早产，132例（8.8%）LBW和123例（8.2%）SGA分娩，平均出生体重为3245.3 g（95% CI，3216.5 - 3274.2）。接种H1N1疫苗的母亲的婴儿早产的几率比未接种疫苗的母亲的婴儿低37%（调整后的比值比，0.63 [95%CI，0.47 - 0.84]）。接种H1N1疫苗的母亲和未接种疫苗的母亲的婴儿之间的平均出生体重差异为45.1 g（95% CI，1.8 - 88.3）。母亲接种H1N1流感疫苗与LBW或SGA之间无显著相关性。 结论：接种H1N1流感疫苗的孕妇早产的可能性较小，且产下的婴儿较重。 这一发现支持美国在2009年甲型H1N1流感大流行期间优先考虑孕妇的疫苗政策选择。
During the 2009 influenza A (H1N1) pandemic, infants of H1N1-vaccinated mothers had 38% lower odds of being born preterm, and were 45.0 g heavier, on average, than infants of unvaccinated mothers. Background. Influenza infection during pregnancy is associated with adverse fetal outcomes such as preterm birth and small for gestational age (SGA). Maternal influenza immunization may prevent these adverse infant outcomes during periods of influenza circulation. Methods. We conducted a retrospective cohort study of live births within Kaiser Permanente (KP) Georgia and Mid-Atlantic States (n = 3327) during the period of 2009 influenza A (H1N1) virus circulation. Primary outcomes were third-trimester preterm birth (27–36 weeks), birth weight, low birth weight (LBW, <2500 g), and SGA. Results. There were 327 (9.8%) preterm, 236 (7.4%) LBW, and 267 (8.4%) SGA births. Among H1N1-vaccinated mothers (n = 1125), there were 86 (7.6%) preterm, 68 (6.4%) LBW, and 99 (9.3%) SGA births, and the mean birth weight was 3308.5 g (95% confidence interval [CI], 3276.6–3340.4). Among unvaccinated mothers (n = 1581), there were 191 (12.1%) preterm, 132 (8.8%) LBW, and 123 (8.2%) SGA births, and the mean birth weight was 3245.3 g (95% CI, 3216.5–3274.2). Infants of H1N1-vaccinated mothers had 37% lower odds of being born preterm than infants of unvaccinated mothers (adjusted odds ratio, 0.63 [95% CI, .47–.84]). The mean birth weight difference between infants of H1N1-vaccinated mothers and infants of unvaccinated mothers was 45.1 g (95% CI, 1.8–88.3). There was no significant association between maternal H1N1 influenza immunization and LBW or SGA. Conclusions. Pregnant women who received H1N1 influenza vaccine were less likely to give birth preterm, and gave birth to heavier infants. The findings support US vaccine policy choices to prioritize pregnant women during the 2009 influenza A (H1N1) pandemic.
登录
查看更多内容
影响因子：
168.9
作者：
Jamieson, Denise J.;Honein, Margaret A.;Olsen, Sonja J.
通讯作者：
Olsen, Sonja J.
影响因子：
9.8
作者：
McNeil, Shelly A.;Dodds, Linda A.;MacDonald, Noni E.
通讯作者：
MacDonald, Noni E.
影响因子：
5.5
作者：
Hardelid, Pia;Fleming, Douglas M.;Pebody, Richard
通讯作者：
Pebody, Richard
影响因子：
2.4
作者：
Oken, Emily;Kleinman, Ken P;Gillman, Matthew W
通讯作者：
Gillman, Matthew W
影响因子：
5.5
作者：
Blanchard-Rohner, Geraldine;Siegrist, Claire-Anne
通讯作者：
Siegrist, Claire-Anne