Ectopic endometrium in human foetuses is a common event and sustains the theory of müllerianosis in the pathogenesis of endometriosis, a disease that predisposes to cancer.
Ectopic endometrium in human foetuses is a common event and sustains the theory of müllerianosis in the pathogenesis of endometriosis, a disease that predisposes to cancer.
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DOI：
10.1186/1756-9966-28-49
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发表时间：
2009-04-09
期刊：
影响因子：
--
通讯作者：
Baldi A
中科院分区：
文献类型：
--
作者：
Signorile PG;Baldi F;Bussani R;D'Armiento M;De Falco M;Baldi A
子宫内膜异位症是一种妇科疾病，其定义为子宫内膜腺体和间质在子宫腔外的组织学存在。患有子宫内膜异位症的女性患不同类型恶性肿瘤的风险增加，尤其是卵巢癌和非霍奇金淋巴瘤。尽管有多种理论，但研究人员仍不确定子宫内膜异位症的确切原因。我们的目的是测试苗勒氏管病理论对子宫内膜异位症的有效性，即原始子宫内膜组织沿着胎儿器官发生的迁移途径错位。我们在尸检中收集了 36 个不同胎龄的人类女性胎儿。我们对36个胎儿的盆腔器官进行了形态学和免疫组织化学研究（雌激素受体和CA125的表达），并进行了整体分析。在 36 个胎儿中，有 4 个胎儿在 5 个不同的异位部位发现了错位的子宫内膜：直肠阴道隔膜、道格拉斯陷凹附近、靠近子宫后壁的间质组织、固有肌层水平的直肠管以及子宫壁。所有这些部位都是女性子宫内膜异位症的常见部位。我们认为子宫内膜异位症的原因是器官发生过程中原始子宫内膜组织脱位到子宫腔外。
Endometriosis is a gynecological disease defined by the histological presence of endometrial glands and stroma outside the uterine cavity. Women with endometriosis have an increased risk of different types of malignancies, especially ovarian cancer and non-Hodgkin's lymphoma. Though there are several theories, researchers remain unsure as to the definitive cause of endometriosis. Our objective was to test the validity of the theory of müllerianosis for endometriosis, that is the misplacing of primitive endometrial tissue along the migratory pathway of foetal organogenesis We have collected at autopsy 36 human female foetuses at different gestational age. We have performed a morphological and immunohistochemical study (expression of oestrogen receptor and CA125) on the pelvic organs of the 36 foetuses included en-block and totally analyzed. In 4 out of 36 foetuses we found presence of misplaced endometrium in five different ectopic sites: in the recto-vaginal septum, in the proximity of the Douglas pouch, in the mesenchimal tissue close to the posterior wall of the uterus, in the rectal tube at the level of muscularis propria, and in the wall of the uterus. All these sites are common location of endometriosis in women. We propose that a cause of endometriosis is the dislocation of primitive endometrial tissue outside the uterine cavity during organogenesis.
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影响因子：
1.8
作者：
Batt, Ronald E;Mitwally, Mohamed F M
通讯作者：
Mitwally, Mohamed F M
影响因子：
2.6
作者：
SCHARL, A;CROMBACH, G;BOLTE, A
通讯作者：
BOLTE, A
影响因子：
6.7
作者：
Nisolle, M;Donnez, J
通讯作者：
Donnez, J
影响因子：
3.3
作者：
Mai, KT;Yazdi, HM;Parks, W
通讯作者：
Parks, W
DOI：
10.1016/j.bpobgyn.2004.01.005
发表时间：
2004-04-01
影响因子：
5.5
作者：
Nap, AW;Groothuis, PG;Dunselman, GAJ
通讯作者：
Dunselman, GAJ