Evaluation of retinal nerve fibre layer thickness as a possible measure of diabetic retinal neurodegeneration in the EPIC-Norfolk Eye Study.
Evaluation of retinal nerve fibre layer thickness as a possible measure of diabetic retinal neurodegeneration in the EPIC-Norfolk Eye Study.
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DOI：
10.1136/bjophthalmol-2021-319853
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发表时间：
2023-05
影响因子：
4.1
通讯作者：
Channa, Roomasa
中科院分区：
文献类型：
--
作者：
Zafar, Sidra;Staggers, Kristen A.;Gao, Jie;Liu, Yao;Patel, Praveen J.;Foster, Paul J.;Frankfort, Benjamin J.;Abramoff, Michael;Minard, Charles G.;Warwick, Alasdair;Khawaja, Anthony P.;Channa, Roomasa
用于临床评估糖尿病性视网膜神经变性 (DRN) 引起的结构变化的标志物尚未确定。为了研究视乳头周围视网膜神经纤维层 (pRNFL) 厚度作为 DRN 标志物的潜在作用，我们评估了糖尿病与血糖控制之间的关系，无论糖尿病状态和 pRNFL 厚度如何。利用基于人群的队列数据，我们使用一般线性混合模型 (GLMM) 对患者和眼睛进行随机截距，在调整典型扫描评分后评估 pRNFL 厚度（使用 GDx 测量）与人口统计学、全身和眼部参数之间的关联。 GLMM 还用于确定：(1) 之间的关系：(A) 糖化血红蛋白 (HbA1c)，无论糖尿病诊断和 pRNFL 厚度如何；(B) 糖尿病和 pRNFL 厚度；(2) 糖尿病参与者中 pRNFL 的哪些象限可能受到影响以及与 HbA1c 的关系。共有 7076 名参与者参与其中。控制协变量后，每增加一个单位，下位 pRNFL 厚度降低 0.94 µm（95% CI -1.28 µm 至 -0.60 µm），上位 pRNFL 厚度降低 0.83 µm（95% CI -1.17 µm 至 -0.49 µm），颞区 pRNFL 厚度升高 1.33 µm（95% CI 0.99 µm 至 -0.67 µm）。糖化血红蛋白 (HbA1c)。鼻 pRNFL 厚度与 HbA1c 没有显着相关性 (p=0.23)。当使用糖尿病作为预测因子时，也出现了类似的趋势。在 HbA1c 水平较高和/或患有糖尿病的人群中，上、下 pRNFL 显着变薄，代表 pRNFL 中可能受糖尿病影响最严重的区域。
Markers to clinically evaluate structural changes from diabetic retinal neurodegeneration (DRN) have not yet been established. To study the potential role of peripapillary retinal nerve fibre layer (pRNFL) thickness as a marker for DRN, we evaluated the relationship between diabetes, as well as glycaemic control irrespective of diabetes status and pRNFL thickness. Leveraging data from a population-based cohort, we used general linear mixed models (GLMMs) with a random intercept for patient and eye to assess the association between pRNFL thickness (measured using GDx) and demographic, systemic and ocular parameters after adjusting for typical scan score. GLMMs were also used to determine: (1) the relationship between: (A) glycated haemoglobin (HbA1c) irrespective of diabetes diagnosis and pRNFL thickness, (B) diabetes and pRNFL thickness and (2) which quadrants of pRNFL may be affected in participants with diabetes and in relation to HbA1c. 7076 participants were included. After controlling for covariates, inferior pRNFL thickness was 0.94 µm lower (95% CI −1.28 µm to −0.60 µm), superior pRNFL thickness was 0.83 µm lower (95% CI −1.17 µm to −0.49 µm) and temporal pRNFL thickness was 1.33 µm higher (95% CI 0.99 µm to 1.67 µm) per unit increase in HbA1c. Nasal pRNFL thickness was not significantly associated with HbA1c (p=0.23). Similar trends were noted when diabetes was used as the predictor. Superior and inferior pRNFL was significantly thinner among those with higher HbA1c levels and/or diabetes, representing areas of the pRNFL that may be most affected by diabetes.
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DOI：
10.1111/j.1559-4564.2006.05513.x
发表时间：
2006-01-01
期刊：
Journal of the cardiometabolic syndrome
影响因子：
--
作者：
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通讯作者：
Stern, Naftali
影响因子：
7.7
作者：
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通讯作者：
Jacobson, AM
影响因子：
4.4
作者：
Bogunovic, Hrvoje;Kwon, Young H.;Abramoff, Michael D.
通讯作者：
Abramoff, Michael D.
影响因子：
5.1
作者：
Cho, N. H.;Shaw, J. E.;Malanda, B.
通讯作者：
Malanda, B.
DOI：
10.20452/pamw.1411
发表时间：
2012-01-01
影响因子：
--
作者：
Araszkiewicz, Aleksandra;Zozulinska-Ziolkiewicz, Dorota;Wierusz-Wysocka, Bogna
通讯作者：
Wierusz-Wysocka, Bogna