Behavioral tests in rodent models of stroke.

Behavioral tests in rodent models of stroke.
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DOI:
10.1016/j.hest.2020.09.001
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发表时间:
2020-12
期刊:
影响因子:
--
通讯作者:
Yao Y
Yao Y
中科院分区:
其他
文献类型:
--
作者:
Ruan J;Yao Y

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啮齿动物是中风研究中最广泛使用的实验动物,因为它们具有相似的血管解剖结构,高繁殖率和转基因模型的可用性。然而,在啮齿类动物中评估高级脑功能(如认知和记忆)的困难降低了这些研究的转化潜力。在这篇综述中,我们总结了常用的运动/感觉运动和认知测试在啮齿动物模型中风。具体来说,我们首先简要介绍了每一个行为测试的目的和程序。接下来,我们总结每种测试在缺血性中风和出血性中风中的应用。最后,这些测试的优点和缺点,在评估中风的结果进行了讨论。本文综述了脑卒中研究中常用的行为测试,并比较了它们在不同类型脑卒中中的应用。
Rodents are the most widely used experimental animals in stroke research due to their similar vascular anatomy, high reproductive rates, and availability of transgenic models. However, the difficulties in assessing higher brain functions, such as cognition and memory, in rodents decrease the translational potential of these studies. In this review, we summarize commonly used motor/sensorimotor and cognition tests in rodent models of stroke. Specifically, we first briefly introduce the objective and procedure of each behavioral test. Next, we summarize the application of each test in both ischemic stroke and hemorrhagic stroke. Last, the advantages and disadvantages of these tests in assessing stroke outcome are discussed. This review summarizes commonly used behavioral tests in stroke studies and compares their applications in different stroke types.
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