Trends in childhood leukemia incidence over two decades from 1992 to 2013.
Trends in childhood leukemia incidence over two decades from 1992 to 2013.
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DOI：
10.1002/ijc.30487
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发表时间：
2017-03-01
影响因子：
6.4
通讯作者：
McKean-Cowdin R
中科院分区：
文献类型：
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作者：
Barrington-Trimis JL;Cockburn M;Metayer C;Gauderman WJ;Wiemels J;McKean-Cowdin R
过去几十年来，美国儿童白血病的发病率稳步上升，但直到最近人们才认识到发病率增长的差异。在当前的分析中，使用监测、流行病学和最终结果 (SEER) 数据来评估 1992 年至 2013 年期间 0-19 岁儿童白血病发病率的总体趋势以及按年龄、种族/民族、性别和组织学亚型划分的趋势。 2009 年至 2013 年期间，西班牙裔白人儿童比非西班牙裔白人、非西班牙裔黑人或非西班牙裔亚裔儿童更有可能被诊断患有急性淋巴细胞白血病 (ALL)。从 1992 年到 2013 年，观察到西班牙裔白人儿童的 ALL 发病率显着增加（年度百分比变化 (APC)西班牙裔=1.08，95%CI：0.59，1.58）；非西班牙裔白人、黑人或亚洲儿童没有观察到显着增加。从 1992 年到 2013 年，15-19 岁诊断的西班牙裔白人儿童的 ALL 发病率每年增加约 3%（APC=2.67；95%CI：0.88，4.49），10-14 岁的儿童 ALL 发病率每年增加 2%（APC=2.09；95%CI：0.57，3.63），而在同龄的非西班牙裔白人、黑人或亚洲儿童。诊断时 1 岁以下的非西班牙裔白人儿童以及 1-4 岁时诊断的西班牙裔白人儿童中，急性髓系白血病 (AML) 发病率有所增加。儿童 ALL 发病率的增加似乎是由西班牙裔大龄儿童（10-14 岁和 15-19 岁）发病率上升推动的。未来的研究需要评估年龄较大的西班牙裔儿童 ALL 增加的原因。
Incidence rates of childhood leukemia in the United States have steadily increased over the last several decades, but only recently have disparities in the increase in incidence been recognized. In the current analysis, Surveillance, Epidemiology and End Results (SEER) data were used to evaluate recent trends in the incidence of childhood leukemia diagnosed at age 0–19 years from 1992–2013, overall and by age, race/ethnicity, gender, and histologic subtype. Hispanic White children were more likely than non-Hispanic White, non-Hispanic Black or non-Hispanic Asian children to be diagnosed with acute lymphocytic leukemia (ALL) from 2009–2013. From 1992–2013, a significant increase in ALL incidence was observed for Hispanic White children (annual percent change (APC)Hispanic=1.08, 95%CI:0.59, 1.58); no significant increase was observed for non-Hispanic White, Black or Asian children. ALL incidence increased by about 3% per year from 1992–2013 for Hispanic White children diagnosed from 15–19 years (APC=2.67; 95%CI:0.88, 4.49), and by 2% for those 10–14 years (APC=2.09; 95%CI:0.57, 3.63), while no significant increases in incidence were observed in non-Hispanic White, Black, or Asian children of the same age. Acute myeloid leukemia (AML) incidence increased among non-Hispanic White children under 1 year at diagnosis, and among Hispanic White children diagnosed at age 1–4. The increase in incidence rates of childhood ALL appears to be driven by rising rates in older Hispanic children (10–14, and 15–19 years). Future studies are needed to evaluate reasons for the increase in ALL among older Hispanic children.
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影响因子：
6.4
作者：
Bailey, Helen D.;Infante-Rivard, Claire;Schuez, Joachim
通讯作者：
Schuez, Joachim
影响因子：
1
作者：
Chokkalingam, Anand P.;Buffler, Patricia A.
通讯作者：
Buffler, Patricia A.
影响因子：
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作者：
Caetano, Raul;Vaeth, Patrice A C;Mills, Britain A
通讯作者：
Mills, Britain A
影响因子：
8.8
作者：
Ahlbom, A;Day, N;Feychting, M;Roman, E;Skinner, J;Dockerty, J;Linet, M;McBride, M;Michaelis, J;Olsen, JH;Tynes, T;Verkasalo, PK
通讯作者：
Verkasalo, PK
影响因子：
6.4
作者：
Caughey, Robert W.;Michels, Karin B.
通讯作者：
Michels, Karin B.