A pooled analysis of magnetic fields and childhood leukaemia.
A pooled analysis of magnetic fields and childhood leukaemia.
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磁场和儿童白血病的汇总分析。
DOI：
10.1054/bjoc.2000.1376
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发表时间：
2000-09
影响因子：
8.8
通讯作者：
Verkasalo, PK
中科院分区：
文献类型：
--
作者：
Ahlbom, A;Day, N;Feychting, M;Roman, E;Skinner, J;Dockerty, J;Linet, M;McBride, M;Michaelis, J;Olsen, JH;Tynes, T;Verkasalo, PK
先前的研究表明，暴露于50-60 Hz磁场（EMF）与儿童白血病之间存在关联。我们根据9项研究（包括最近的研究）的个体记录进行了汇总分析。纳入了24/48小时磁场测量或计算磁场的研究。在开始工作之前，我们详细说明了我们计划进行哪些数据分析以及如何进行这些分析。个体记录的使用使我们能够使用相同的暴露定义，并且大量的受试者能够更精确地估计高暴露水平下的风险。对于估计住宅磁场暴露水平< 0.4 μT的3203名白血病儿童和10338名对照儿童，我们观察到风险估计接近无影响水平，而对于估计住宅磁场暴露水平≥ 0.4 μT的44名白血病儿童和62名对照儿童，估计的汇总相对风险为2.00（1.27-3.13），P值= 0.002）。潜在混杂变量的调整没有明显改变结果。对于居住在最高有线编码类别中的北美受试者，估计的汇总相对风险为1.24（0.82-1.87）。因此，我们在合并的数据中没有发现所谓的线码悖论存在的证据。总之，99.2%的儿童居住在暴露水平< 0.4 μT的家庭中，其估计值与无风险增加一致，而0.8%的儿童暴露水平≥ 0.4 μT，其相对风险估计值约为2，这不太可能是由于随机变异性。风险升高的原因尚不清楚，但选择偏倚可能是导致风险增加的原因。2000癌症研究运动
Previous studies have suggested an association between exposure to 50–60 Hz magnetic fields (EMF) and childhood leukaemia. We conducted a pooled analysis based on individual records from nine studies, including the most recent ones. Studies with 24/48-hour magnetic field measurements or calculated magnetic fields were included. We specified which data analyses we planned to do and how to do them before we commenced the work. The use of individual records allowed us to use the same exposure definitions, and the large numbers of subjects enabled more precise estimation of risks at high exposure levels. For the 3203 children with leukaemia and 10 338 control children with estimated residential magnetic field exposures levels < 0.4 μT, we observed risk estimates near the no effect level, while for the 44 children with leukaemia and 62 control children with estimated residential magnetic field exposures ≥ 0.4 μT the estimated summary relative risk was 2.00 (1.27–3.13), P value = 0.002). Adjustment for potential confounding variables did not appreciably change the results. For North American subjects whose residences were in the highest wire code category, the estimated summary relative risk was 1.24 (0.82–1.87). Thus, we found no evidence in the combined data for the existence of the so-called wire-code paradox. In summary, the 99.2% of children residing in homes with exposure levels < 0.4 μT had estimates compatible with no increased risk, while the 0.8% of children with exposures ≥ 0.4 μT had a relative risk estimate of approximately 2, which is unlikely to be due to random variability. The explanation for the elevated risk is unknown, but selection bias may have accounted for some of the increase. © 2000 Cancer Research Campaign
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影响因子：
7.7
作者：
WERTHEIMER, N;LEEPER, E
通讯作者：
LEEPER, E
影响因子：
5
作者：
FEYCHTING, M;AHLBOM, A
通讯作者：
AHLBOM, A
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OLSEN, JH;NIELSEN, A;SCHULGEN, G
通讯作者：
SCHULGEN, G
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作者：
WERTHEIMER, N;LEEPER, E
通讯作者：
LEEPER, E
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作者：
Green, LM;Miller, AB;Tibshirani, R
通讯作者：
Tibshirani, R