Who's in control? Regulation of metabolism and pathogenesis in space and time.
Who's in control? Regulation of metabolism and pathogenesis in space and time.
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谁在掌控？
DOI：
10.1016/j.mib.2020.05.009
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发表时间：
2020
影响因子：
5.4
通讯作者：
Brinsmade,ShaunR
中科院分区：
文献类型：
--
作者：
King,AlyssaN;deMets,François;Brinsmade,ShaunR
亮点调节剂充当遗传“时间回路”来调节代谢和毒力。代谢通量的改变对生存和致病潜力具有深远影响。宿主信号或营养物质可以影响不同空间尺度上的基因表达。空间和时间线索导致代谢和表型异质性。细菌病原体在感染过程中需要感知和响应其环境以调整细胞 新陈代谢和毒力因子的产生以生存并对抗宿主防御。复杂的调控网络包括配体结合转录因子、双组分系统、RNA 结合蛋白和小非编码调控 RNA，可根据代谢通量、环境线索和营养可用性的变化来调整基因表达程序。最近的研究强调，这些不同层次的调控发生在不同的空间和时间尺度上，导致细胞行为和细菌群落异质性的变化。这篇简短的综述将重点介绍当前的研究，强调革兰氏阳性菌和革兰氏阴性菌的细胞代谢和发病机制密不可分。
HighlightsRegulators act as genetic ‘time circuits’ to adjust metabolism and virulence.Altered metabolic flux has profound effects on survival and pathogenic potential.Host signals or nutrients can affect gene expression on various spatial scales.Spatial and temporal cues result in metabolic and phenotypic heterogeneity.Bacterial pathogens need to sense and respond to their environments during infection to align cell metabolism and virulence factor production to survive and battle host defenses. Complex regulatory networks including ligand-binding transcription factors, two-component systems, RNA-binding proteins, and small non-coding regulatory RNAs adjust gene expression programs in response to changes in metabolic fluxes, environmental cues, and nutrient availability. Recent studies underlined that these different layers of regulation occur along varying spatial and temporal scales, leading to changes in cell behavior and heterogeneity among the bacterial community. This brief review will highlight current research emphasizing that cell metabolism and pathogenesis are inextricably intertwined in both Gram-positive and Gram-negative bacteria.
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