The emerging importance of ultradian glucocorticoid rhythms within metabolic pathology.
The emerging importance of ultradian glucocorticoid rhythms within metabolic pathology.
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DOI:
10.1016/j.ando.2018.03.003
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发表时间:
2018-06
期刊:
影响因子:
--
通讯作者:
Lightman SL
中科院分区:
文献类型:
--
作者:
Flynn BP;Conway-Campbell BL;Lightman SL
Glucocorticoid (GC) hormones play significant roles within homeostasis and the chrono-dynamics of their regulatory role has become increasingly recognised within dysregulated GC pathology, particularly with metabolic phenotypes. Within this article, we will discuss the relevance of the ultradian homeostatic rhythm, how its dysregulation effects glucocorticoid receptor and RNA polymeraseII recruitment and may play a significant role within aberrant metabolic action.
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