Measuring pulmonary gas exchange using compartment-selective xenon-polarization transfer contrast (XTC) MRI.
Measuring pulmonary gas exchange using compartment-selective xenon-polarization transfer contrast (XTC) MRI.
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DOI：
10.1002/mrm.28626
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发表时间：
2021-05
影响因子：
3.3
通讯作者：
Rizi RR
中科院分区：
文献类型：
--
作者：
Amzajerdian F;Ruppert K;Hamedani H;Baron R;Xin Y;Loza L;Achekzai T;Duncan IF;Qian Y;Pourfathi M;Kadlecek S;Rizi RR
为了证明利用氙偏振转移对比（XTC）磁共振成像生成红细胞（RBC）和组织/血浆（TP）特异性气相（GP）去极化图的可行性。对三名健康受试者，一名无症状吸烟者和一名慢性阻塞性肺病患者进行影像学检查。单次呼吸XTC数据是通过在屏气12 s期间使用二维多层GRE的一系列三张GP图像获得的。在图像之间应用一系列间隔30 ms的8 ms高斯反转脉冲，以量化GP和DP隔室之间的交换。反转脉冲要么以共振为中心以产生对比度，要么以非共振为中心以校正其他信号损失源。作为一种替代方案，插入RBC和TP共振的反转来代替非共振脉冲。最后，将该技术扩展到与潮汐呼吸一致的多呼吸协议，涉及30个连续采集。倒置脉冲偏移20 ppm以模拟RBC和TP共振之间的距离，显示了选择性，初始GP去极化图显示了健康和患病受试者之间明显的幅度和分布差异，这与传统方法一致。所提出的dp -室选择性XTC MRI技术提供了肺中所有三种可检测氙状态之间气体交换的信息，并且足够敏感，可以指示研究对象之间肺功能的差异。研究了这种方法在成像方案中的扩展，以最大限度地减少屏气时间或屏气总数，为未来的研究开辟了道路，以提高测量精度和患者舒适度。
To demonstrate the feasibility of generating red blood cell (RBC) and tissue/plasma (TP) specific gas-phase (GP) depolarization maps using Xenon-Polarization Transfer Contrast (XTC) MR imaging. Imaging was performed in three healthy subjects, an asymptomatic smoker, and a COPD patient. Single-breath XTC data were acquired through a series of three GP images using a 2D multi-slice GRE during a 12 s breath-hold. A series of 8 ms Gaussian inversion pulses spaced 30 ms apart were applied in-between the images to quantify the exchange between the GP and dissolved-phase (DP) compartments. Inversion pulses were either centered on-resonance to generate contrast, or off-resonance to correct for other sources of signal loss. For an alternative scheme, inversions of both RBC and TP resonances were inserted in lieu of off-resonance pulses. Finally, this technique was extended to a multi-breath protocol consistent with tidal breathing, involving 30 consecutive acquisitions. Inversion pulses shifted off-resonance by 20 ppm to mimic the distance between the RBC and TP resonances demonstrated selectivity, and initial GP depolarization maps illustrated stark magnitude and distribution differences between healthy and diseased subjects that were consistent with traditional approaches. The proposed DP-compartment selective XTC MRI technique provides information on gas exchange between all three detectable states of xenon in the lungs and is sufficiently sensitive to indicate differences in lung function between the study subjects. Investigated extensions of this approach to imaging schemes that either minimize breath-hold duration or the overall number of breath-holds open avenues for future research to improve measurement accuracy and patient comfort.
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影响因子：
19.7
作者：
Driehuys, Bastiaan;Martinez-Jimenez, Santiago;McAdams, H. Page
通讯作者：
McAdams, H. Page
影响因子：
3.3
作者：
Mugler, JP;Driehuys, B;Wagshul, ME
通讯作者：
Wagshul, ME
影响因子：
4.4
作者：
Hahn, Andrew D.;Kammerman, Jeff;Fain, Sean B.
通讯作者：
Fain, Sean B.
DOI：
10.1073/pnas.1011912107
发表时间：
2010-12-14
影响因子：
11.1
作者：
Mugler, John P., III;Altes, Talissa A.;Ruppert, Kai
通讯作者：
Ruppert, Kai
影响因子：
19.7
作者：
Kirby, Miranda;Svenningsen, Sarah;Parraga, Grace
通讯作者：
Parraga, Grace