GABA transmission from mAL interneurons regulates aggression in Drosophila males.
GABA transmission from mAL interneurons regulates aggression in Drosophila males.
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DOI：
10.1073/pnas.2117101119
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发表时间：
2022-02-01
影响因子：
11.1
通讯作者：
Kravitz EA
中科院分区：
文献类型：
--
作者：
Sengupta S;Chan YB;Palavicino-Maggio CB;Kravitz EA
几乎所有动物的攻击性都取决于同种动物的性别。但是，性别特异性化学感受信号如何调节攻击性的神经元基础却知之甚少。使用果蝇模型的果蝇黑腹，我们表明，激活一组GABA能中枢脑神经元，已知响应性特异性信息素刺激，增强侵略性的二进制男性的遭遇。这个神经元群的失活降低了攻击性，增加了求爱的互惠社会行为。我们的研究结果可以帮助追踪从感觉神经元中的信息素处理到中枢脑中的行为整合的神经回路，并最终帮助理解神经元如何编码攻击行为。在许多物种中，攻击行为都受到信息素的调控。但是中枢神经元如何处理这些信息来调节攻击性却知之甚少。使用果蝇模型的果蝇，我们系统地描述了一组性别二型GABA能中枢神经元，俗称mAL，在侵略调节的作用。已知mAL神经元被雄性和雌性信息素激活。在这份报告中，我们表明，mAL激活强烈增加侵略，而其失活减少侵略和增加雄性间的求爱，一种行为被认为是相互侵略。来自mAL的GABA神经传递对于这种行为调节至关重要。利用果蝇模型的遗传工具包，我们还发现了一个小组的大约三至五个GABA+中枢脑神经元的解剖相似性MAL.Activation的MAL类似组的神经元是必要的，以增加雄性间的侵略。总的来说，我们的研究结果表明，GABA+中枢脑神经元处理信息素信息的活动变化，如黑腹果蝇中的mAL，直接调节雄性-雄性配对中的攻击性社会行为。
Aggression is dependent on the sex of the conspecific in almost all animal species. But the neuronal basis of how sex-specific chemosensory signals regulate aggression is poorly understood. Using the fruit fly model of Drosophila melanogaster, we demonstrate that activation of a group of GABAergic central brain neurons, known to respond to sex-specific pheromonal stimuli, enhances aggression in dyadic male encounters. Inactivation of this neuronal group decreases aggression and increases the reciprocal social behavior of courtship. Our results can help trace the neural circuit from pheromone processing in the sensory neurons to behavior integration in the central brain and ultimately help understand how neurons encode the behavior of aggression. Aggression is known to be regulated by pheromonal information in many species. But how central brain neurons processing this information modulate aggression is poorly understood. Using the fruit fly model of Drosophila melanogaster, we systematically characterize the role of a group of sexually dimorphic GABAergic central brain neurons, popularly known as mAL, in aggression regulation. The mAL neurons are known to be activated by male and female pheromones. In this report, we show that mAL activation robustly increases aggression, whereas its inactivation decreases aggression and increases intermale courtship, a behavior considered reciprocal to aggression. GABA neurotransmission from mAL is crucial for this behavior regulation. Exploiting the genetic toolkit of the fruit fly model, we also find a small group of approximately three to five GABA+ central brain neurons with anatomical similarities to mAL. Activation of the mAL resembling group of neurons is necessary for increasing intermale aggression. Overall, our findings demonstrate how changes in activity of GABA+ central brain neurons processing pheromonal information, such as mAL in Drosophila melanogaster, directly modulate the social behavior of aggression in male–male pairings.
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DOI：
10.1073/pnas.1506763112
发表时间：
2015-06-02
影响因子：
11.1
作者：
Nern, Aljoscha;Pfeiffer, Barret D.;Rubin, Gerald M.
通讯作者：
Rubin, Gerald M.
影响因子：
56.9
作者：
Ferveur, JF;Savarit, F;Jallon, JM
通讯作者：
Jallon, JM
影响因子：
64.8
作者：
Kurtovic, Amina;Widmer, Alexandre;Dickson, Barry J.
通讯作者：
Dickson, Barry J.
影响因子：
7.7
作者：
Hoopfer, Eric D.;Jung, Yonil;Anderson, David J.
通讯作者：
Anderson, David J.
影响因子：
8.8
作者：
Jenett, Arnim;Rubin, Gerald M.;Zugates, Christopher T.
通讯作者：
Zugates, Christopher T.