Association Between Breastfeeding Initiation and Duration and Autism Spectrum Disorder in Preschool Children Enrolled in the Study to Explore Early Development.
Association Between Breastfeeding Initiation and Duration and Autism Spectrum Disorder in Preschool Children Enrolled in the Study to Explore Early Development.
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DOI：
10.1002/aur.2091
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发表时间：
2019-05
期刊：
影响因子：
--
通讯作者：
Schieve LA
中科院分区：
文献类型：
--
作者：
Soke GN;Maenner M;Windham G;Moody E;Kaczaniuk J;DiGuiseppi C;Schieve LA
研究报告了ASD和母乳喂养之间关系的不一致结果。我们在探索早期发育的研究中探索了ASD与母乳喂养开始（是/否）和持续时间（按三分位数分类的月数）之间的关联，这是一项在美国六个地点进行的基于社区的病例对照研究。我们调整了各种儿童和母亲的人口统计和怀孕因素。据报道，85.7%的ASD儿童母亲和90.6%的对照组母亲开始母乳喂养。调整后，我们发现母乳喂养开始没有显着差异（调整后的比值比[aOR]：0.88和95%置信区间（CI）0.60-1.28）。然而，ASD儿童的母亲报告母乳喂养持续时间的可能性较低，在高（≥12个月）与低三分位数（<6个月）（aOR和95%CI：0.61 [0.45-0.84]）或中间（6-<12个月）与低三分位数（0.72：0.54-0.98）。当考虑到母亲中存在更广泛的自闭症表型（BAP）时，ASD和母乳喂养持续时间的关联略有减弱，但仍然保持在最高的三分位数。这种关联似乎不能完全用母体BAP来解释。我们无法区分持续时间的差异是否是由于难以母乳喂养后来发展为ASD的儿童，我们研究中未调整的其他因素，或由于母乳喂养时间较短而导致的更大ASD风险。需要进行纵向研究，比较ASD和对照组母亲停止母乳喂养的原因，并建立ASD和母乳喂养之间的时间关系。未来的研究还应该评估ASD风险基因和母乳喂养之间的相互作用。在这项研究中，我们比较了患有和没有自闭症谱系障碍（ASD）儿童的母亲之间的母乳喂养实践。我们发现，两组开始母乳喂养的母亲的比例相似，但与没有ASD的儿童的母亲相比，ASD儿童的母亲母乳喂养的时间更短。未来的研究需要评估为什么ASD儿童的母亲母乳喂养的持续时间比没有ASD的母亲短的原因。
Studies report inconsistent findings on the relationship between ASD and breastfeeding. We explored associations between ASD and breastfeeding initiation (yes/no) and duration (months categorized in tertiles) in the Study to Explore Early Development, a community-based case–control study in six sites in the Unites States. We adjusted for various child and mother demographic and pregnancy factors. Breastfeeding initiation was reported in 85.7% of mothers of children with ASD and 90.6% of mothers of controls. After adjustment, we found no significant difference in breastfeeding initiation (adjusted odds-ratio [aOR]: 0.88 and 95% confidence interval (CI) 0.60–1.28). However, mothers of children with ASD were less likely to report duration of breastfeeding in the high (≥12 months) versus low tertile (<6 months) (aOR and 95% CI: 0.61 [0.45–0.84]) or the middle (6–<12 months) versus low tertile (0.72: 0.54–0.98). The association of ASD and breastfeeding duration was slightly attenuated when the presence of the broader autism phenotype (BAP) in the mother was accounted for, but still remained for the highest tertile. This association does not appear to be totally explained by maternal BAP. We were unable to distinguish whether the difference in duration was due to difficulties breastfeeding children who later develop ASD, other factors not adjusted in our study, or greater ASD risk resulting from shorter breastfeeding duration. Longitudinal studies that compare reasons why mothers stop breastfeeding between ASD and controls and establish a temporal relation between ASD and breastfeeding are needed. Future studies should also evaluate interactions between ASD risk genes and breastfeeding. In this study, we compared breastfeeding practices between mothers of children with and without autism spectrum disorder (ASD). We found that the percentage of mothers who started breastfeeding was similar between the two groups, but mothers of children with ASD breastfed for a shorter amount of time compared to mothers of children without ASD. Future studies are needed to evaluate the reasons why the duration of breastfeeding was shorter for mothers of children with ASD compared to those without ASD.
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影响因子：
10.6
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