Oxidized low-density lipoprotein receptor 1: a novel potential therapeutic target for intracerebral hemorrhage.
Oxidized low-density lipoprotein receptor 1: a novel potential therapeutic target for intracerebral hemorrhage.
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DOI：
10.4103/1673-5374.332157
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发表时间：
2022-08
影响因子：
6.1
通讯作者：
He ZY
中科院分区：
文献类型：
--
作者：
Zhang HY;Lu X;Hao YH;Tang L;He ZY
氧化低密度脂蛋白受体1（OLR 1）在神经元中上调，并参与高血压诱导的神经元凋亡。OLR 1基因缺失对高血压脑卒中所致脑损伤具有保护作用。因此，OLR 1很可能参与了脑出血的进展。在这项研究中，我们使用大鼠模型研究了OLR 1在脑出血中的潜在作用。将OLR 1小干扰RNA（10 μL; 50 pmol/μL）注射到右侧基底神经节中以敲低OLR 1。24 h后注射0.5 U VII型胶原酶诱导脑出血。我们发现，敲低OLR 1可减轻脑出血大鼠的神经行为障碍，并减少大鼠脑组织中的血肿、神经元丢失、炎症反应和氧化应激。我们还发现，OLR 1的沉默抑制脑出血和p38信号通路诱导的铁凋亡。因此，沉默OLR 1对脑出血继发性损伤具有保护作用。这些发现表明OLR 1可能是脑出血治疗的一个新的潜在靶点。
Oxidized low-density lipoprotein receptor 1 (OLR1) is upregulated in neurons and participates in hypertension-induced neuronal apoptosis. OLR1 deletion exerts protective effects on cerebral damage induced by hypertensive-induced stroke. Therefore, OLR1 is likely involved in the progress of intracerebral hemorrhage. In this study, we examined the potential role of OLR1 in intracerebral hemorrhage using a rat model. OLR1 small interfering RNA (10 μL; 50 pmol/μL) was injected into the right basal ganglia to knock down OLR1. Twenty-four hours later, 0.5 U collagenase type VII was injected to induce intracerebral hemorrhage. We found that knockdown of OLR1 attenuated neurological behavior impairment in rats with intracerebral hemorrhage and reduced hematoma, neuron loss, inflammatory reaction, and oxidative stress in rat brain tissue. We also found that silencing of OLR1 suppressed ferroptosis induced by intracerebral hemorrhage and the p38 signaling pathway. Therefore, silencing OLR1 exhibits protective effects against secondary injury of intracerebral hemorrhage. These findings suggest that OLR1 may be a novel potential therapeutic target for intracerebral hemorrhage.
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影响因子：
5.6
作者：
Duan L;Zhang Y;Yang Y;Su S;Zhou L;Lo PC;Cai J;Qiao Y;Li M;Huang S;Wang H;Mo Y;Wang Q
通讯作者：
Wang Q
影响因子：
4.6
作者：
Li C;Zhang J;Wu H;Li L;Yang C;Song S;Peng P;Shao M;Zhang M;Zhao J;Zhao R;Wu W;Ruan Y;Wang L;Gu J
通讯作者：
Gu J
影响因子：
5
作者：
Hu, Changping;Chen, Jiawei;Mehta, Jawahar L.
通讯作者：
Mehta, Jawahar L.
氧化型低密度脂蛋白受体1通过调节上皮间质转化促进骨肉瘤肺转移
影响因子：
7.4
作者：
Jiang, Long;Jiang, Shanshan;Luo, Qingquan
通讯作者：
Luo, Qingquan
DOI：
10.19540/j.cnki.cjcmm.20161222.076
发表时间：
2017-02-01
期刊：
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
影响因子：
--
作者：
Guo, Jian-En;Mi, Shu-Bin;Li, Jing-Hua
通讯作者：
Li, Jing-Hua