APOE related hippocampal shape alteration in geriatric depression.
APOE related hippocampal shape alteration in geriatric depression.
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DOI：
10.1016/j.neuroimage.2008.10.010
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发表时间：
2009-02-01
期刊：
影响因子：
5.7
通讯作者：
Krishnan KR
中科院分区：
文献类型：
--
作者：
Qiu A;Taylor WD;Zhao Z;MacFall JR;Miller MI;Key CR;Payne ME;Steffens DC;Krishnan KR
迟发性抑郁症通常先于与海马变性相关的痴呆发作。采用大变形差形测量制图（LDDMM），我们评估了载脂蛋白E ε -4等位基因（apoE E4）对38例无apoE E4的抑郁症患者、14例有1个apoE E4的抑郁症患者和31例无apoE E4的健康对照者的海马体积和形状的影响。人工评估海马体积。我们应用了一个差胚模板生成程序来创建基于种群子集的海马模板。LDDMM映射用于生成每个受试者的海马形状，并表征每个海马相对于模板的表面变形。这种变形被建模为随机场，在模板坐标中以Laplace-Beltrami基函数表征。线性回归分析各组海马体积和形状的差异。我们发现抑郁组和健康组的海马形状有明显的变化，而抑郁组和健康组的海马体积没有差异。与没有apoE E4的健康对照相比，携带一个apoE E4的抑郁症患者在CA1前区表现出更明显的形状内压。因此，携带一种apoE E4的晚发性抑郁症患者的海马形状异常可能表明，与没有携带apoE E4的抑郁症患者相比，这组患者未来转化为AD的风险更高。
Late-onset depression often precedes the onset of dementia associated with the hippocampal degeneration. Using large deformation diffeomorphic metric mapping (LDDMM), we evaluated apolipoprotein E epsilon-4 allele (apoE E4) effects on hippocampal volume and shape in 38 depressed patients without the apoE E4, 14 depressed patients with one apoE E4, and 31 healthy comparison subjects without the apoE E4. The hippocampal volumes were manually assessed. We applied a diffeomorphic template generation procedure for creating the hippocampal templates based on a subset of the population. The LDDMM mappings were used to generate hippocampal shapes for each subject and characterize the surface deformation of each hippocampus relative to the template. Such deformation was modeled as random field characterized by the Laplace-Beltrami basis functions in the template coordinates. Linear regression was used to examine group differences in the hippocampal volume and shape. We found that there were significant hippocampal shape alternations in both depressed groups while the groups of depressed patients and the group of healthy subjects did not differ in the hippocampal volume. The depressed patients with one apoE E4 show more pronounced shape inward-compression in the anterior CA1 than the depressed patients without the apoE E4 when compared with the healthy controls without the apoE E4. Thus, hippocampal shape abnormalities in late-onset depressed patients with one apoE E4 may indicate future conversion of this group to AD at higher risk than depressed patients without the apoE E4.
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DOI：
10.1073/pnas.0503892102
发表时间：
2005-07-05
影响因子：
11.1
作者：
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影响因子：
5.7
作者：
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