Striatal dopamine D2-like receptor correlation patterns with human obesity and opportunistic eating behavior.
Striatal dopamine D2-like receptor correlation patterns with human obesity and opportunistic eating behavior.
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DOI：
10.1038/mp.2014.102
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发表时间：
2014-10
影响因子：
11
通讯作者：
Hall, K. D.
中科院分区：
文献类型：
--
作者：
Guo, J.;Simmons, W. K.;Herscovitch, P.;Martin, A.;Hall, K. D.
肥胖症的流行被认为是由促进消费廉价，方便，高热量，可口的食物的食品环境驱动的。肥胖易感性或体重减轻阻力的个体差异可能是由于支持食物奖励和饮食习惯的神经回路的改变而产生的。特别是，腹内侧纹状体中的多巴胺信号被认为编码食物奖励和动机，而背侧和侧纹状体中的多巴胺协调饮食习惯的发展。我们使用正电子发射断层扫描（PET）与[18 F]fallypride测量了43名体重指数（BMI）范围为18-45 kg/m2的人类受试者的纹状体多巴胺D2样受体结合电位（D2 BP）。强迫性进食行为和BMI均与背侧和外侧纹状体的D2 BP呈正相关，而BMI与腹内侧纹状体的D2 BP呈负相关。这些结果表明，肥胖者的多巴胺神经回路发生了改变，这可能会增加他们对机会性暴饮暴食的易感性，同时使食物摄入的回报减少，目标导向性降低，习惯性增加。无论观察到的神经回路改变是否预先存在或作为肥胖发展的结果而发生，它们都可能使肥胖永久化，因为可口的食物及其相关线索无处不在。
The obesity epidemic is believed to be driven by a food environment that promotes consumption of inexpensive, convenient, high-calorie, palatable foods. Individual differences in obesity susceptibility or resistance to weight loss may arise due to alterations in the neurocircuitry supporting food reward and eating habits. In particular, dopamine signaling in the ventromedial striatum is thought to encode food reward and motivation, whereas dopamine in the dorsal and lateral striatum orchestrates the development of eating habits. We measured striatal dopamine D2-like receptor binding potential (D2BP) using positron emission tomography (PET) with [18F]fallypride in 43 human subjects with body mass indices (BMI) ranging from 18–45 kg/m2. Opportunistic eating behavior and BMI were both positively associated with D2BP in the dorsal and lateral striatum, whereas BMI was negatively associated with D2BP in the ventromedial striatum. These results suggest that obese people have alterations in dopamine neurocircuitry that may increase their susceptibility to opportunistic overeating while at the same time making food intake less rewarding, less goal-directed, and more habitual. Whether or not the observed neurocircuitry alterations pre-existed or occurred as a result of obesity development, they may perpetuate obesity given the omnipresence of palatable foods and their associated cues.
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影响因子：
25
作者：
Rangel, Antonio
通讯作者：
Rangel, Antonio
影响因子：
168.9
作者：
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通讯作者：
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影响因子：
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通讯作者：
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