The effect of age on relational encoding as revealed by hippocampal functional connectivity.
The effect of age on relational encoding as revealed by hippocampal functional connectivity.
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DOI：
10.1016/j.nlm.2016.07.026
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发表时间：
2016-10
影响因子：
2.7
通讯作者：
Giovanello KS
中科院分区：
文献类型：
--
作者：
Foster CM;Picklesimer ME;Mulligan NW;Giovanello KS
调节认知的神经过程发生在分布于整个大脑的网络中。关系记忆的编码和检索，对多个项目或多特征事件的记忆，是由大脑区域网络，特别是海马体支持的。海马耦合假说认为，海马在检索过程中与默认模式网络（DMN）存在功能连接，但在编码过程中与DMN分离。基于先前的研究表明，老年人在大脑网络状态之间的调节能力较差，我们验证了老年人的海马体在关系编码过程中与DMN表现出功能连接的假设。结果表明，尽管在关系编码过程中，年轻人和老年人的海马体在功能上与DMN的某些区域相连，但老年人表现出额外的DMN连接。这种与年龄相关的网络调节变化似乎不是由代偿过程介导的，而是反映了一种神经效率低下的形式，最有可能是由于抑制减少。
The neural processes mediating cognition occur in networks distributed throughout the brain. The encoding and retrieval of relational memories, memories for multiple items or multifeatural events, is supported by a network of brain regions, particularly the hippocampus. The hippocampal coupling hypothesis suggests that the hippocampus is functionally connected with the default mode network (DMN) during retrieval, but during encoding, decouples from the DMN. Based on prior research suggesting that older adults are less able to modulate between brain network states, we tested the hypothesis that older adults’ hippocampus would show functional connectivity with the DMN during relational encoding. The results suggest that, while the hippocampus is functionally connected to some regions of the DMN during relational encoding in both younger and older adults, older adults show additional DMN connectivity. Such age-related changes in network modulation appear not to be mediated by compensatory processes, but rather to reflect a form of neural inefficiency, most likely due to reduced inhibition.
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影响因子：
5.7
作者：
Andrews-Hanna JR;Saxe R;Yarkoni T
通讯作者：
Yarkoni T
DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
3.2
作者：
Grady, CL;Springer, MV;Winocur, G
通讯作者：
Winocur, G
DOI：
10.1073/pnas.2235925100
发表时间：
2003-11-25
影响因子：
11.1
作者：
Lustig, C;Snyder, AZ;Buckner, RL
通讯作者：
Buckner, RL
影响因子：
3.2
作者：
EICHENBAUM, H
通讯作者：
EICHENBAUM, H