Contributions of episodic retrieval and mentalizing to autobiographical thought: evidence from functional neuroimaging, resting-state connectivity, and fMRI meta-analyses.
Contributions of episodic retrieval and mentalizing to autobiographical thought: evidence from functional neuroimaging, resting-state connectivity, and fMRI meta-analyses.
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DOI：
10.1016/j.neuroimage.2014.01.032
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发表时间：
2014-05-01
期刊：
影响因子：
5.7
通讯作者：
Yarkoni T
中科院分区：
文献类型：
--
作者：
Andrews-Hanna JR;Saxe R;Yarkoni T
越来越多的研究表明，当人们回忆自己的过去或模拟自己的未来时，大脑的“默认网络”就会活跃起来。最近的网络内的异质性的报告提出的可能性，这些自传体的过程是由多个组件的过程，每个支持不同的功能解剖子系统。我们以前假设，一个内侧颞子系统有助于自传体记忆和未来的想法，使个人能够检索先前的信息，并将这些信息绑定到一个心理场景。相反，背内侧子系统被提出来支持自传体思维的社会反思方面，允许个体反思自己和他人的精神状态（即“心智化”）。为了验证这些假设，我们首先检查了默认网络子系统中的活动，参与者进行了两个常用的任务，情节检索和心理化。在一个子集的参与者，任务诱发区域之间的关系进行了检查，在休息时，在没有一个明显的任务。最后，进行大规模的功能磁共振成像荟萃分析，以确定大脑区域，最强烈地预测存在的情节检索和心理化，这些结果进行了比较，自传体任务的荟萃分析。跨研究，实验室为基础的情节检索任务优先链接到内侧颞子系统，而mentalizing任务优先链接到背内侧子系统。反过来，自传体任务从事两个子系统的方面。这些结果表明，默认网络是一个异质的大脑系统，其子系统支持自传体思维的不同组成过程。
A growing number of studies suggest the brain’s “default network” becomes engaged when individuals recall their personal past or simulate their future. Recent reports of heterogeneity within the network raises the possibility that these autobiographical processes are comprised of multiple component processes, each supported by distinct functional-anatomic subsystems. We previously hypothesized that a medial temporal subsystem contributes to autobiographical memory and future thought by enabling individuals to retrieve prior information and bind this information into a mental scene. Conversely, a dorsal medial subsystem was proposed to support social-reflective aspects of autobiographical thought, allowing individuals to reflect on the mental states of one’s self and others (i.e. “mentalizing”). To test these hypotheses, we first examined activity in the default network subsystems as participants performed two commonly employed tasks of episodic retrieval and mentalizing. In a subset of participants, relationships among task-evoked regions were examined at rest, in the absence of an overt task. Finally, large-scale fMRI meta-analyses were conducted to identify brain regions that most strongly predicted the presence of episodic retrieval and mentalizing, and these results were compared to meta-analyses of autobiographical tasks. Across studies, laboratory-based episodic retrieval tasks were preferentially linked to the medial temporal subsystem, while mentalizing tasks were preferentially linked to the dorsal medial subsystem. In turn, autobiographical tasks engaged aspects of both subsystems. These results suggest the default network is a heterogeneous brain system whose subsystems support distinct component processes of autobiographical thought.
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DOI：
10.1177/1073858411403316
发表时间：
2012-06
期刊：
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
影响因子：
--
作者：
Andrews-Hanna JR
通讯作者：
Andrews-Hanna JR
影响因子：
2.6
作者：
Conway, Martin A.
通讯作者：
Conway, Martin A.
影响因子：
2.5
作者：
Andrews-Hanna, Jessica R.;Reidler, Jay S.;Buckner, Randy L.
通讯作者：
Buckner, Randy L.
影响因子：
4.2
作者：
Contreras, Juan Manuel;Banaji, Mahzarin R.;Mitchell, Jason P.
通讯作者：
Mitchell, Jason P.
影响因子：
3.2
作者：
Cabeza, R;Prince, SE;Rubin, DC
通讯作者：
Rubin, DC