Serum 25-hydroxyvitamin D, vitamin D binding protein and risk of colorectal cancer in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial.
Serum 25-hydroxyvitamin D, vitamin D binding protein and risk of colorectal cancer in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial.
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DOI：
10.1002/ijc.29157
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发表时间：
2015-03-15
影响因子：
6.4
通讯作者：
Albanes, Demetrius
中科院分区：
文献类型：
--
作者：
Weinstein, Stephanie J.;Purdue, Mark P.;Smith-Warner, Stephanie A.;Mondul, Alison M.;Black, Amanda;Ahn, Jiyoung;Huang, Wen-Yi;Horst, Ronald L.;Kopp, William;Rager, Helen;Ziegler, Regina G.;Albanes, Demetrius
维生素D在预防癌症方面的潜在作用引起了人们的极大兴趣，实验室实验表明，维生素D化合物具有几种抗癌特性。对循环25-羟基维生素D[25(OH)D]的前瞻性研究表明，循环中的25-羟基维生素D[25(OH)D]是维生素D状态的公认生物标志物，与结直肠癌风险呈负相关，但存在一些不一致。此外，尚未研究关键运输蛋白--维生素D结合蛋白(DBP)的直接或间接影响。在前列腺癌、肺癌、结直肠癌和卵巢癌筛查试验中，我们对血清25(OH)D和DBP浓度与结直肠癌风险进行了一项前瞻性研究，该研究基于476例结直肠癌病例和476名对照，年龄、性别、种族和血清收集日期匹配。所有受试者在基线和随访期间均接受乙状结肠镜检查。条件Logistic回归估计的优势比(OR)和95%可信区间(CI)。循环25(OH)D与结直肠癌呈负相关(OR=0.60，95%CI 0.38~0.94，P趋势0.01)。对公认的结直肠癌风险因素进行调整，并考虑到维生素D的季节性变化，并没有改变研究结果。循环DBP和25(OH)D：DBP摩尔比(25(OH)D：DBP摩尔比)与风险无关(OR=0.82，95%可信区间0.54~1.26，OR=0.79，95%可信区间0.52~1.21)，且DBP不改变25(OH)D关联。目前的研究消除了结直肠癌筛查行为的混淆，并支持较高的维生素D水平与显著较低的结直肠癌风险之间的关联，但并未表明DBP具有直接或修饰作用。
The potential role of vitamin D in cancer prevention has generated substantial interest, and laboratory experiments indicate several anti-cancer properties for vitamin D compounds. Prospective studies of circulating 25-hydroxyvitamin D [25(OH)D], the accepted biomarker of vitamin D status, suggest an inverse association with colorectal cancer risk, but with some inconsistencies. Furthermore, the direct or indirect impact of the key transport protein, vitamin D binding protein (DBP), has not been examined. We conducted a prospective study of serum 25(OH)D and DBP concentrations and colorectal cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, based on 476 colorectal cancer cases and 476 controls, matched on age, sex, race, and date of serum collection. All subjects underwent sigmoidoscopic screening at baseline and once during follow-up. Conditional logistic regression estimated odds ratios (ORs) and 95% confidence intervals (CIs). Circulating 25(OH)D was inversely associated with colorectal cancer (OR=0.60, 95% CI 0.38-0.94 for highest versus lowest quintile, p-trend 0.01). Adjusting for recognized colorectal cancer risk factors and accounting for seasonal vitamin D variation did not alter the findings. Neither circulating DBP nor the 25(OH)D:DBP molar ratio, a proxy for free circulating 25(OH)D, was associated with risk (OR=0.82, 95% CI 0.54-1.26, and OR=0.79, 95% CI 0.52-1.21, respectively), and DBP did not modify the 25(OH)D association. The current study eliminated confounding by colorectal cancer screening behavior, and supports an association between higher vitamin D status and substantially lower colorectal cancer risk, but does not indicate a direct or modifying role for DBP.
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影响因子：
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