The brain-derived neurotrophic-factor (BDNF) val66met polymorphism is associated with geriatric depression: a meta-analysis.
The brain-derived neurotrophic-factor (BDNF) val66met polymorphism is associated with geriatric depression: a meta-analysis.
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脑源性神经营养因子 (BDNF) val66met 多态性与老年抑郁症相关：一项荟萃分析。
DOI：
10.1002/ajmg.b.32062
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发表时间：
2012-07
影响因子：
2.8
通讯作者：
Ma, Xin
中科院分区：
文献类型：
--
作者：
Pei, Yu;Smith, Alicia K.;Wang, Yongjun;Pan, Yanli;Yang, Jian;Chen, Qi;Pan, Weigang;Bao, Feng;Zhao, Lisha;Tie, Changle;Wang, Yizheng;Wang, Jian;Zhen, Wenfeng;Zhou, Jinxia;Ma, Xin
抑郁症与海马体中脑源性神经营养因子（BDNF）表达减少有关。 BDNF Val66Met 多态性 (rs6265) 与老年抑郁症的遗传关联研究产生了不一致的结果。对研究进行荟萃分析，比较老年抑郁症病例和年龄匹配对照之间 BDNF Val66Met 变异的频率。总共纳入了五项研究，涉及 523 名老年抑郁症患者和 1,220 名精神健康对照者。与 Val/Val 纯合子相比，Met 等位基因携带者患老年抑郁症的风险增加（P = 0.004，OR = 1.48，95% CI = 1.13–1.93）。我们的研究结果表明，随着个体年龄的增长，BDNF Met 等位基因可能会增加患抑郁症的风险。
Depression has been associated with reduced expression of brain-derived neurotrophic factor (BDNF) in the hippocampus. Genetic association studies of the BDNF Val66Met polymorphism (rs6265) in geriatric depression have produced inconsistent results. A meta-analysis of studies was conducted to compare the frequency of the BDNF Val66Met variant between cases with geriatric depression and age-matched controls. A total of five studies involving 523 cases with geriatric depression and 1,220 psychiatrically healthy controls was included. Met allele carriers had an increased risk for geriatric depression when compared to Val/Val homozygotes (P =0.004, OR =1.48, 95% CI =1.13–1.93). Our findings suggest the BDNF Met allele may confer increased risk for depression as individual age.
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影响因子：
5.3
作者：
Chen, ZY;Ieraci, A;Lee, FS
通讯作者：
Lee, FS
DOI：
10.1177/1073858410397054
发表时间：
2012-02
期刊：
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
影响因子：
--
作者：
Erickson KI;Miller DL;Roecklein KA
通讯作者：
Roecklein KA
影响因子：
11
作者：
Glatt, SJ;Faraone, SV;Tsuang, MT
通讯作者：
Tsuang, MT
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
影响因子：
10.5
作者：
Copeland, JRM;Beekman, ATF;Wilson, KCM
通讯作者：
Wilson, KCM