Circadian neurons in the paraventricular nucleus entrain and sustain daily rhythms in glucocorticoids.
Circadian neurons in the paraventricular nucleus entrain and sustain daily rhythms in glucocorticoids.
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DOI：
10.1038/s41467-021-25959-9
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发表时间：
2021-10-01
影响因子：
16.6
通讯作者：
Herzog ED
中科院分区：
文献类型：
--
作者：
Jones JR;Chaturvedi S;Granados-Fuentes D;Herzog ED
来自中央昼夜节律起搏器，视交叉上核（SCN）的信号必须解码才能产生激素释放的日常节律。在这里，我们假设SCN在室旁核（PVN）中携带节律以确定皮质酮的每日释放时间。体内记录揭示了从SCN血管活性肠肽（SCNVIP）产生神经元到PVN促肾上腺皮质激素释放激素（PVNCRH）产生神经元的关键回路。PVNCRH神经元的时钟基因表达在中午左右达到峰值，三小时后钙活性达到峰值。CRH神经元中时钟基因Bmal1的缺失导致PVNCRH钙活性紊乱，并显著降低每日皮质酮释放的幅度和精度。SCNVIP激活减少（而失活增加）皮质酮释放和PVNCRH钙活性，每日SCNVIP激活通过抑制PVNCRH神经元来携带PVN时钟基因节律。我们得出结论，在SCNVIP和PVNCRH神经元中，皮质酮的每日释放取决于协调的时钟基因和神经元活动节律。目前尚不清楚如何解码来自视交叉上核（SCN）的昼夜节律信号以产生激素释放的日常节律。在这里，作者表明皮质酮的每日释放取决于协调时钟基因和神经元活动节律在SCN和室旁核神经元。
Signals from the central circadian pacemaker, the suprachiasmatic nucleus (SCN), must be decoded to generate daily rhythms in hormone release. Here, we hypothesized that the SCN entrains rhythms in the paraventricular nucleus (PVN) to time the daily release of corticosterone. In vivo recording revealed a critical circuit from SCN vasoactive intestinal peptide (SCNVIP)-producing neurons to PVN corticotropin-releasing hormone (PVNCRH)-producing neurons. PVNCRH neurons peak in clock gene expression around midday and in calcium activity about three hours later. Loss of the clock gene Bmal1 in CRH neurons results in arrhythmic PVNCRH calcium activity and dramatically reduces the amplitude and precision of daily corticosterone release. SCNVIP activation reduces (and inactivation increases) corticosterone release and PVNCRH calcium activity, and daily SCNVIP activation entrains PVN clock gene rhythms by inhibiting PVNCRH neurons. We conclude that daily corticosterone release depends on coordinated clock gene and neuronal activity rhythms in both SCNVIP and PVNCRH neurons. It is unclear how circadian signals from the suprachiasmatic nucleus (SCN) are decoded to generate daily rhythms in hormone release. Here, the authors show that daily corticosterone release depends on coordinated clock gene and neuronal activity rhythms in both SCN and paraventricular nucleus neurons.
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影响因子：
4.8
作者：
Brum MC;Filho FF;Schnorr CC;Bottega GB;Rodrigues TC
通讯作者：
Rodrigues TC
影响因子：
3.4
作者：
Buijs, RM;Wortel, J;Kalsbeek, A
通讯作者：
Kalsbeek, A
DOI：
10.1152/ajpendo.1996.270.2.e238
发表时间：
1996-02-01
影响因子：
5.1
作者：
Cai, AH;Wise, PM
通讯作者：
Wise, PM
影响因子：
4.8
作者：
DAVIDNELSON, MA;BRODISH, A
通讯作者：
BRODISH, A
影响因子：
--
作者：
ALEXANDER, LD;SANDER, LD
通讯作者：
SANDER, LD