The Anti-Obesity Effect of Traditional Chinese Medicine on Lipid Metabolism.
The Anti-Obesity Effect of Traditional Chinese Medicine on Lipid Metabolism.
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中药对脂质代谢的抗肥胖作用
DOI：
10.3389/fphar.2021.696603
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发表时间：
2021
影响因子：
5.6
通讯作者：
Zou X
中科院分区：
文献类型：
--
作者：
Fan Q;Xu F;Liang B;Zou X
随着生活条件的改善和不健康饮食生活习惯的普及，肥胖正在成为一种全球性的流行病。肥胖现在被认为是一种疾病，不仅会增加代谢性疾病（如2型糖尿病（T2D）、非酒精性脂肪性肝病（NAFLD）、心血管疾病（CVD）和癌症）的风险，而且还会对寿命和生活质量产生负面影响。中药富含生物活性化合物，长期以来被用于治疗肥胖和与肥胖相关的代谢疾病。在这篇综述中，我们选择了最常用的抗肥胖或抗高脂血症中药，以及已知的主要生物活性化合物。然后总结了它们的多靶点分子机制，特别关注脂质代谢，包括调节脂质吸收，减少脂质合成，增加脂质分解和脂质转运，以及调节食欲。本文综述了中药抗肥胖的综合系统机制。我们还提倡利用中药作为干预肥胖相关疾病的另一种疗法，并强调需要做更多的工作，科学地确定中药的活性化合物和作用方式。
With the improvement of living conditions and the popularity of unhealthy eating and living habits, obesity is becoming a global epidemic. Obesity is now recognized as a disease that not only increases the risk of metabolic diseases such as type 2 diabetes (T2D), non-alcoholic fatty liver disease (NAFLD), cardiovascular disease (CVD), and cancer but also negatively affects longevity and the quality of life. The traditional Chinese medicines (TCMs) are highly enriched in bioactive compounds and have been used for the treatment of obesity and obesity-related metabolic diseases over a long period of time. In this review, we selected the most commonly used anti-obesity or anti-hyperlipidemia TCMs and, where known, their major bioactive compounds. We then summarized their multi-target molecular mechanisms, specifically focusing on lipid metabolism, including the modulation of lipid absorption, reduction of lipid synthesis, and increase of lipid decomposition and lipid transportation, as well as the regulation of appetite. This review produces a current and comprehensive understanding of integrative and systematic mechanisms for the use of TCMs for anti-obesity. We also advocate taking advantage of TCMs as another therapy for interventions on obesity-related diseases, as well as stressing the fact that more is needed to be done, scientifically, to determine the active compounds and modes of action of the TCMs.
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影响因子：
4.6
作者：
Cunha CA;Lira FS;Rosa Neto JC;Pimentel GD;Souza GI;da Silva CM;de Souza CT;Ribeiro EB;Sawaya AC;Oller do Nascimento CM;Rodrigues B;de Oliveira Carvalho P;Oyama LM
通讯作者：
Oyama LM
影响因子：
7.2
作者：
Cao, Zhen-Hui;Gu, Da-Hai;Ge, Chang-Rong
通讯作者：
Ge, Chang-Rong
丹酚酸通过阻断 STAT-3/SREBP1 信号传导改善卵巢切除大鼠的肝脏脂质代谢
影响因子：
4.6
作者：
Chen Juan;Yue Jia;Li Yuan
通讯作者：
Li Yuan
影响因子：
7.5
作者：
Choi, Ra-Yeong;Lee, Hae-In;Lee, Mi-Kyung
通讯作者：
Lee, Mi-Kyung
DOI：
10.1016/j.ecl.2008.08.005
发表时间：
2008-12
影响因子：
4.5
作者：
Ahima, Rexford S.;Antwi, Daniel A.
通讯作者：
Antwi, Daniel A.