Green tea extract supplementation induces the lipolytic pathway, attenuates obesity, and reduces low-grade inflammation in mice fed a high-fat diet.
Green tea extract supplementation induces the lipolytic pathway, attenuates obesity, and reduces low-grade inflammation in mice fed a high-fat diet.
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DOI：
10.1155/2013/635470
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发表时间：
2013
影响因子：
4.6
通讯作者：
Oyama LM
中科院分区：
文献类型：
--
作者：
Cunha CA;Lira FS;Rosa Neto JC;Pimentel GD;Souza GI;da Silva CM;de Souza CT;Ribeiro EB;Sawaya AC;Oller do Nascimento CM;Rodrigues B;de Oliveira Carvalho P;Oyama LM
本研究的目的是评估绿茶茶提取物对饮食诱导的肥胖小鼠脂肪组织中促炎分子和脂解蛋白水平的影响。动物被随机分为四组：CW（食物和水）； CG（食物和水+绿茶提取物）； HW（高脂肪饮食和水）； HG（高脂肪饮食和水+绿茶提取物）。小鼠随意喂食食物或高脂肪饮食，同时补充（口服强饲）400mg/kg体重/天的绿茶提取物（分别为CG和HG）。治疗进行了八周。 UPLC结果显示，10mg/mL绿茶提取物中，表没食子儿茶素含量为15μg/mg，表没食子儿茶素没食子酸酯含量为95μg/mg，表儿茶素没食子酸酯含量为20.8μg/mg，表儿茶素没食子酸酯含量为4.9μg/mg。绿茶与高脂肪饮食同时服用会增加肠系膜脂肪组织中的 HSL、ABHD5 和周脂肪素，这与体重减轻和脂肪组织增加有关。此外，我们观察到补充绿茶可降低炎症细胞因子 TNFα 水平以及 TLR4、MYD88 和 TRAF6 促炎症信号传导。我们的结果表明，绿茶增加了脂肪分解途径并减少了脂肪组织，这可能解释了肥胖小鼠低度炎症的减弱。
The aim of this study was to evaluate the effects of green tea Camellia sinensis extract on proinflammatory molecules and lipolytic protein levels in adipose tissue of diet-induced obese mice. Animals were randomized into four groups: CW (chow diet and water); CG (chow diet and water + green tea extract); HW (high-fat diet and water); HG (high-fat diet and water + green tea extract). The mice were fed ad libitum with chow or high-fat diet and concomitantly supplemented (oral gavage) with 400 mg/kg body weight/day of green tea extract (CG and HG, resp.). The treatments were performed for eight weeks. UPLC showed that in 10 mg/mL green tea extract, there were 15 μg/mg epigallocatechin, 95 μg/mg epigallocatechin gallate, 20.8 μg/mg epicatechin gallate, and 4.9 μg/mg gallocatechin gallate. Green tea administered concomitantly with a high-fat diet increased HSL, ABHD5, and perilipin in mesenteric adipose tissue, and this was associated with reduced body weight and adipose tissue gain. Further, we observed that green tea supplementation reduced inflammatory cytokine TNFα levels, as well as TLR4, MYD88, and TRAF6 proinflammatory signalling. Our results show that green tea increases the lipolytic pathway and reduces adipose tissue, and this may explain the attenuation of low-grade inflammation in obese mice.
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影响因子：
9.3
作者：
Pajonk F;Riedisser A;Henke M;McBride WH;Fiebich B
通讯作者：
Fiebich B
影响因子：
39.2
作者：
Iso, H;Date, C;Tamakoshi, A
通讯作者：
Tamakoshi, A
影响因子：
4.8
作者：
Lin, Y;Lee, H;Scherer, PE
通讯作者：
Scherer, PE
影响因子：
6.3
作者：
Hsu, Chung-Hua;Tsai, Tung-Hu;Chou, Pesus
通讯作者：
Chou, Pesus
DOI：
10.1080/07315724.2010.10719814
发表时间：
2010-02-01
影响因子：
3.5
作者：
Basu, Arpita;Sanchez, Karah;Lyons, Timothy J.
通讯作者：
Lyons, Timothy J.