Oral drug delivery with polymeric nanoparticles: the gastrointestinal mucus barriers.
Oral drug delivery with polymeric nanoparticles: the gastrointestinal mucus barriers.
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DOI：
10.1016/j.addr.2011.12.009
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发表时间：
2012-05-01
影响因子：
16.1
通讯作者：
Hanes, Justin
中科院分区：
文献类型：
--
作者：
Ensign, Laura M.;Cone, Richard;Hanes, Justin
口服给药是最常用的给药方法。然而，许多药物的溶解度、稳定性和生物利用度差使得通过胃肠道（GI）达到治疗水平具有挑战性。药物递送必须克服许多障碍，包括酸性胃环境和保护胃肠道的粘液的持续分泌。纳米颗粒药物载体可以保护药物免于降解并将其递送到胃肠道内的预期部位，这可以实现更有效和持续的药物递送。然而，胃肠道粘液的快速分泌和脱落可显著限制纳米颗粒药物递送系统的有效性。许多类型的纳米颗粒被有效地捕获在粘液中并被粘液快速去除，使得难以在胃肠道中控制释放。本文综述了粘液分泌物的保护性屏障特性，粘液如何影响口服纳米颗粒的命运，以及最近开发的纳米颗粒工程穿透粘液屏障。
Oral delivery is the most common method for drug administration. However, poor solubility, stability, and bioavailability of many drugs make achieving therapeutic levels via the gastrointestinal (GI) tract challenging. Drug delivery must overcome numerous hurdles, including the acidic gastric environment and the continuous secretion of mucus that protects the GI tract. Nanoparticle drug carriers that can shield drugs from degradation and deliver them to intended sites within the GI tract may enable more efficient and sustained drug delivery. However, the rapid secretion and shedding of GI tract mucus can significantly limit the effectiveness of nanoparticle drug delivery systems. Many types of nanoparticles are efficiently trapped in and rapidly removed by mucus, making controlled release in the GI tract difficult. This review addresses the protective barrier properties of mucus secretions, how mucus affects the fate of orally administered nanoparticles, and recent developments in nanoparticles engineered to penetrate the mucus barrier.
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影响因子：
1.9
作者：
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通讯作者：
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DOI：
10.1111/j.1440-1746.1994.tb01303.x
发表时间：
1994-01-01
影响因子：
4.1
作者：
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通讯作者：
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