Vitamin D attenuates inflammation, fatty infiltration, and cartilage loss in the knee of hyperlipidemic microswine.
Vitamin D attenuates inflammation, fatty infiltration, and cartilage loss in the knee of hyperlipidemic microswine.
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DOI：
10.1186/s13075-016-1099-6
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发表时间：
2016-09-13
影响因子：
4.9
通讯作者：
Agrawal DK
中科院分区：
文献类型：
--
作者：
Rai V;Dietz NE;Dilisio MF;Radwan MM;Agrawal DK
膝关节骨关节炎（OA）是一种导致软骨丢失的退行性过程。最近的证据表明，骨关节炎不仅仅是一种软骨疾病，而是整个膝关节的疾病，炎症可能起重要作用。OA与维生素D缺乏有关。维生素D作为一种免疫调节剂和抗炎剂可以减轻膝关节炎症。本研究的目的是评估维生素D对膝关节炎症的抗炎作用。本研究对13只高胆固醇饮食的微型猪进行了研究，将其分为维生素D缺乏组、维生素D充足组和维生素D补充组三组。1年后，处死微猪，取其膝关节组织。对组织标本进行组织学和免疫荧光研究，以评估维生素D状态的影响。膝关节组织的组织学和免疫荧光研究显示：(1)膝关节组织炎症增加；(2)四头肌、髌骨肌腱和副韧带的脂肪浸润；(3)与维生素D补充组相比，维生素D缺乏组和维生素D充足组的软骨细胞聚集。在维生素d缺乏组的炎症灶和脂肪浸润区也可见股四头肌、髌骨肌腱和副韧带的结构扭曲。维生素D补充组炎症和脂肪浸润的减少表明维生素D在减轻炎症和脂肪浸润以及保护膝关节组织结构方面的潜在作用。本文的在线版本（doi:10.1186/s13075-016-1099-6）包含补充材料，可供授权用户使用。
Osteoarthritis (OA) of the knee joint is a degenerative process resulting in cartilage loss. Recent evidence suggests that OA is not merely a disease of cartilage but a disease of the entire knee joint and that inflammation may play an important role. OA has been associated with vitamin D deficiency. Vitamin D as an immunomodulator and anti-inflammatory agent may attenuate inflammation in the knee. The aim of this study was to assess the anti-inflammatory effect of vitamin D on inflammation in the knee. This study was conducted with 13 microswine on a high cholesterol diet categorized into three groups of vitamin D-deficient, vitamin D-sufficient, and vitamin D supplementation. After 1 year, microswine were killed, and their knee joint tissues were harvested. Histological and immunofluorescence studies were carried out on the tissue specimens to evaluate the effect of vitamin D status. Histological and immunofluorescence studies of the knee joint tissues showed (1) increased inflammation in the knee joint tissues, (2) fatty infiltration in quadriceps muscle, patellar tendon, and collateral ligaments, and (3) chondrocyte clustering in the vitamin D-deficient and vitamin D-sufficient groups compared with the vitamin D supplementation group. Architectural distortion of the quadriceps muscle, patellar tendon, and collateral ligaments was also seen in the areas of inflammatory foci and fatty infiltration in the vitamin D-deficient group. Decreased inflammation and fatty infiltration in the vitamin D supplementation group suggest the potential role of vitamin D in attenuating inflammation and fatty infiltration as well as in protecting the architecture of the tissue in the knee joint. The online version of this article (doi:10.1186/s13075-016-1099-6) contains supplementary material, which is available to authorized users.
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滑膜巨噬细胞和巨噬细胞产生的细胞因子在驱动聚集蛋白聚糖酶、基质金属蛋白酶和骨关节炎中其他破坏性和炎症反应中的作用。
影响因子：
4.9
作者：
Bondeson J;Wainwright SD;Lauder S;Amos N;Hughes CE
通讯作者：
Hughes CE
影响因子：
2.8
作者：
Goula, Thomais;Kouskoukis, Alexandros;Kazakos, Konstantinos
通讯作者：
Kazakos, Konstantinos
影响因子：
2.9
作者：
Dean, DD;Schwartz, Z;Boyan, BD
通讯作者：
Boyan, BD
影响因子：
5
作者：
Houston, Denise K.;Tooze, Janet A.;Kritchevsky, Stephen B.
通讯作者：
Kritchevsky, Stephen B.
影响因子：
2.8
作者：
Hoshiyama, Yoshiaki;Otsuki, Shuhei;Oda, Shuhei;Kurokawa, Yoshitaka;Nakajima, Mikio;Jotoku, Tsuyoshi;Tamura, Ryuichi;Okamoto, Yoshinori;Lotz, Martin K.;Neo, Masashi
通讯作者：
Neo, Masashi