Three-dimensional whole-brain simultaneous T1, T2, and T1ρ quantification using MR Multitasking: Method and initial clinical experience in tissue characterization of multiple sclerosis.
Three-dimensional whole-brain simultaneous T1, T2, and T1ρ quantification using MR Multitasking: Method and initial clinical experience in tissue characterization of multiple sclerosis.
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DOI：
10.1002/mrm.28553
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发表时间：
2021-04
影响因子：
3.3
通讯作者：
Li D
中科院分区：
文献类型：
--
作者：
Ma S;Wang N;Fan Z;Kaisey M;Sicotte NL;Christodoulou AG;Li D
开发一种具有MR多任务的3D全脑同步T1/T2/T1ρ定量方法，该方法可在9 min内提供高质量、共配准的多参数图。MR多任务将T1/T2/T1ρ弛豫概念化为不同的时间维度，同时使用低秩张量图像模型解决所有三个维度。该方法在体模和健康志愿者中进行了验证，将定量测量结果与相应的参考方法进行了比较，并评估了扫描重扫描的重复性。在年龄匹配的复发缓解型多发性硬化症（RRMS）患者中进行了初步临床验证，以检查定量组织表征的可行性，并与健康对照组进行比较。还研究了合成六个对比加权图像的可行性。我们的框架生成了高质量的、共配准的T1/T2/T1ρ图，这些图与参考图非常相似。多任务T1/T2/T1ρ测量结果与体模和健康对照的参考测量结果基本一致。Bland-Altman分析表明所有三个参数的体内重复性良好。在RRMS患者中，病变在所有三种地图和四种合成加权图像（T2加权，T2-FLAIR，双反转恢复和新型“T1ρ-FLAIR”对比）上均被明显描绘。T1和T2显示患者和对照组之间正常外观的白色物质存在显著差异，而T1ρ显示正常外观的白色物质、皮质灰质和深部灰质存在显著差异。与单独使用任何单一参数相比，三个参数的组合显著改善了RRMS患者和健康对照之间的区分。MR多任务同时量化全脑T1/T2/T1ρ，在临床上有望用于MS等神经系统疾病的定量组织定征。
To develop a 3D whole-brain simultaneous T1/T2/T1ρ quantification method with MR Multitasking that provides high quality, co-registered multiparametric maps in 9min. MR Multitasking conceptualizes T1/T2/T1ρ relaxations as different time dimensions, simultaneously resolving all three dimensions with a low-rank tensor image model. The proposed method was validated on a phantom and in healthy volunteers, comparing quantitative measurements against corresponding reference methods and evaluating the scan-rescan repeatability. Initial clinical validation was performed in age-matched relapsing-remitting multiple sclerosis (RRMS) patients to examine the feasibility of quantitative tissue characterization and to compare with the healthy control cohort. The feasibility of synthesizing six contrast-weighted images was also examined. Our framework produced high quality, co-registered T1/T2/T1ρ maps that closely resemble the reference maps. Multitasking T1/T2/T1ρ measurements showed substantial agreement with reference measurements on the phantom and in healthy controls. Bland-Altman analysis indicated good in vivo repeatability of all three parameters. In RRMS patients, lesions were conspicuously delineated on all three maps and on four synthetic weighted images (T2-weighted, T2-FLAIR, double inversion recovery, and a novel “T1ρ-FLAIR” contrast). T1 and T2 showed significant differences for normal appearing white matter between patients and controls, while T1ρ showed significant differences for normal appearing white matter, cortical gray matter, and deep gray matter. The combination of three parameters significantly improved the differentiation between RRMS patients and healthy controls, as compared to using any single parameter alone. MR Multitasking simultaneously quantifies whole-brain T1/T2/T1ρ and is clinically promising for quantitative tissue characterization of neurological diseases such as MS.
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影响因子：
3.3
作者：
Huang, Chuan;Graff, Christian G.;Clarkson, Eric W.;Bilgin, Ali;Altbach, Maria I.
通讯作者：
Altbach, Maria I.
影响因子：
3.4
作者：
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通讯作者：
Granziera C
影响因子：
3.3
作者：
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通讯作者：
Wang, Yi
影响因子：
3.5
作者：
Blystad, I.;Hakansson, I.;Larsson, E-M.
通讯作者：
Larsson, E-M.
影响因子：
6
作者：
Haris M;Singh A;Cai K;Davatzikos C;Trojanowski JQ;Melhem ER;Clark CM;Borthakur A
通讯作者：
Borthakur A