A prospective cohort study of physical activity in relation to lung cancer incidence among Black women.
A prospective cohort study of physical activity in relation to lung cancer incidence among Black women.
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DOI：
10.1016/j.canep.2022.102146
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发表时间：
2022-06
影响因子：
2.6
通讯作者：
Adams-Campbell, Lucile L.
中科院分区：
文献类型：
--
作者：
Bethea, Traci N.;Dash, Chiranjeev;Adams-Campbell, Lucile L.
尽管黑人女性的吸烟率低于白人女性，但黑人女性的肺癌发病率和死亡率高于白人女性。体育锻炼可能通过几个途径降低患肺癌的风险，包括免疫和炎症系统，以及那些对性激素和新陈代谢有影响的途径。我们调查了38,432名黑人女性队列中的38,432名参与者的剧烈体育活动、散步锻炼、坐着看电视和代谢当量(METS)与肺癌风险的关系。我们使用经协变量调整的Cox比例风险模型来估计危险比(HR)和95%可信区间(CI)。从1995年到2017年，累计发生肺癌病例475例。每周从事≥1小时剧烈运动或消耗蛋氨酸三分位数最高的参与者患肺癌的风险降低(HR：0.85，95%CI：0.65~1.10；0.89，0.68~1.18；)。观察到坐着看电视的风险增加(≥1小时/周：1.27，0.72-2.21)。在分层模型中，只有既往吸烟者(≥1小时/周：0.71，0.52-0.98)与运动步行与肺癌风险呈负相关，而在吸烟20包年的吸烟者中，剧烈体力活动(≥1小时/周：0.45，0.28-0.73)和蛋氨酸(3，34-0.85)与肺癌风险呈负相关。体育活动可能在降低黑人女性患肺癌风险方面发挥作用，特别是在吸烟者中。未来的研究应该探索体育活动可能影响癌症发生的生物学机制，并调查运动干预在降低吸烟者肺癌风险方面的作用。
Black women have higher lung cancer incidence and mortality rates despite a lower smoking prevalence than White women. Physical activity may reduce lung cancer risk through several pathways, including the immune and inflammatory systems, as well as those with effects on sex hormones and metabolism. We examined vigorous physical activity, walking for exercise, sitting watching television, and metabolic equivalents (METs) in relation to lung cancer risk among 38,432 participants in a prospective cohort of Black women. We used Cox proportional hazards models adjusted for covariates to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). From 1995 to 2017, 475 incident lung cancer cases accrued. Participants who engaged in ≥1 hour/week of vigorous physical activity or expended the highest tertile of METs experienced a decreased risk of lung cancer (HR: 0.85, 95% CI: 0.65–1.10; 0.89, 0.68–1.18; respectively). An increased risk was observed for sitting watching television (≥1 hour/week: 1.27, 0.72–2.21). In stratified models, an inverse association between walking for exercise and lung cancer risk was only present among former smokers (≥1 hour/week: 0.71, 0.52–0.98), while inverse associations between vigorous physical activity (≥1 hour/week: 0.45, 0.28–0.73) and METs (tertile 3: 0.54, 0.34–0.85) and lung cancer risk were present among smokers with ≥20 pack-years. Physical activity may play a role in reducing lung cancer risk among Black women, particularly among smokers. Future studies should explore biologic mechanisms whereby physical activity may influence carcinogenesis and investigate the role of exercise interventions in reducing lung cancer risk among smokers.
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影响因子：
5.5
作者：
Prizment, Anna E.;Yatsuya, Hiroshi;Huxley, Rachel R.
通讯作者：
Huxley, Rachel R.
影响因子：
1.4
作者：
Ridge, Carole A.;McErlean, Aoife M.;Ginsberg, Michelle S.
通讯作者：
Ginsberg, Michelle S.
影响因子：
3.7
作者：
Bedard, Annabelle;Carsin, Anne-Elie;Garcia-Aymerich, Judith
通讯作者：
Garcia-Aymerich, Judith
影响因子：
2.3
作者：
Bethea, Traci N.;Rosenberg, Lynn;Charlot, Marjory;O'Connor, George T.;Adams-Campbell, Lucile L.;Palmer, Julie R.
通讯作者：
Palmer, Julie R.
DOI：
10.5114/aoms.2012.31614
发表时间：
2012-11-09
期刊：
Archives of medical science : AMS
影响因子：
--
作者：
Ertek S;Cicero A
通讯作者：
Cicero A