Upregulation of SQLE Contributes to Poor Survival in Head and Neck Squamous Cell Carcinoma.
Upregulation of SQLE Contributes to Poor Survival in Head and Neck Squamous Cell Carcinoma.
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角鲨烯环氧酶（SQLE）的上调与头颈部鳞状细胞癌患者生存率低下相关。
DOI：
10.7150/ijbs.68216
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发表时间：
2022
影响因子：
9.2
通讯作者：
Li, Jinfeng
中科院分区：
文献类型：
--
作者：
Li, Jing;Yang, Tao;Wang, Qihong;Li, Yuedan;Wu, Haiyan;Zhang, Mei;Qi, Hong;Zhang, Hongxin;Li, Jinfeng
最近，角鲨烯环氧酶（SQLE）在几种类型的癌症中的作用越来越受到关注。然而，其在头颈部鳞状细胞癌（HNSCC）的肿瘤进展中的功能作用仍不清楚。我们通过生物信息学分析和相关实验来评估SQLE介导的HNSCC恶性肿瘤的潜在机制。结果表明，与癌旁组织相比，肿瘤组织中SQLE表达显著上调。从机制上讲，miR-584- 5 p下调可能导致HNSCC中SQLE的上调。SQLE在HNSCC中的高表达与TNM分期、远处转移和生存率相关，提示SQLE可能参与了HNSCC的进展。SQLE能促进HNSCC细胞的增殖、迁移和侵袭。生物信息学研究表明，PI 3 K/Akt信号通路参与了SQLE过表达介导的HNSCC进展，这一点已被体内外分析所证实。特别地，用广泛用于治疗真菌感染的SQLE抑制剂特比萘芬治疗显示出对HNSCC的治疗影响。我们的研究结果表明SQLE在HNSCC的进展中起着至关重要的作用，为SQLE作为HNSCC的治疗靶点和特比萘芬作为HNSCC治疗的候选药物提供了研究依据
Recently, increasing attention has been paid to the role of Squalene epoxidase (SQLE) in several types of cancers. However, its functional role in tumor progression of head and neck squamous cell carcinoma (HNSCC) is still unclear. We performed bioinformatic analyses and relative experiments to assess the potential mechanism of SQLE-mediated HNSCC malignancy. And the results showed that SQLE was significantly upregulated in tumor samples compared with peritumor samples. Mechanistically, miR-584-5p downregulation may lead to the upregulation of SQLE in HNSCC. Moreover, high SQLE expression in HNSCC was associated with TNM stage, distant metastasis, and poor survival, indicating that SQLE be involved in the progression of HNSCC. Furtherly, SQLE boosted proliferation, migration, invasion of HNSCC cells in vitro and in vivo. Bioinformatic studies showed that PI3K/Akt signaling participated in HNSCC progression mediated by SQLE overexpression, which is confirmed by in vitro and in vivo analysis. Particularly, treatment with terbinafine, an inhibitor of SQLE widely used in the treatment of fungal infections, showed a therapeutic influence on HNSCC. Our findings demonstrate that SQLE plays a vital role in HNSCC progression, providing research evidence for SQLE as a prospective HNSCC therapeutic target and for terbinafine as a candidate drug of HNSCC treatment in the future
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影响因子：
7.3
作者：
Gao J;Aksoy BA;Dogrusoz U;Dresdner G;Gross B;Sumer SO;Sun Y;Jacobsen A;Sinha R;Larsson E;Cerami E;Sander C;Schultz N
通讯作者：
Schultz N
影响因子：
11.2
作者：
Stopsack KH;Gerke TA;Sinnott JA;Penney KL;Tyekucheva S;Sesso HD;Andersson SO;Andrén O;Cerhan JR;Giovannucci EL;Mucci LA;Rider JR
通讯作者：
Rider JR
DOI：
10.1146/annurev.pathol.4.110807.092222
发表时间：
2009
期刊：
Annual review of pathology
影响因子：
--
作者：
Lee YS;Dutta A
通讯作者：
Dutta A
影响因子：
3.7
作者：
Sticht C;De La Torre C;Parveen A;Gretz N
通讯作者：
Gretz N
影响因子：
14.9
作者：
Ritchie ME;Phipson B;Wu D;Hu Y;Law CW;Shi W;Smyth GK
通讯作者：
Smyth GK