Reversal of glial and neurovascular markers of unhealthy brain aging by exercise in middle-aged female mice.
Reversal of glial and neurovascular markers of unhealthy brain aging by exercise in middle-aged female mice.
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DOI：
10.1371/journal.pone.0026812
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Porter NM
中科院分区：
文献类型：
--
作者：
Latimer CS;Searcy JL;Bridges MT;Brewer LD;Popović J;Blalock EM;Landfield PW;Thibault O;Porter NM
运动可以促进健康的大脑衰老和认知功能。运动的好处归因于几种机制，其中许多机制通过促进神经发生、神经元形态和/或神经营养素释放来突出其神经保护作用。然而，大脑也是由神经胶质和血管成分组成的，关于运动对老化大脑中这些成分的影响，我们知道的相对较少。在这里，我们表明，中年的有氧运动减少了不健康的大脑老化的标志，包括星形胶质细胞肥大，这是大脑老化的标志。中年雌性小鼠被分配到久坐不动的组，或提供一个跑轮六周。运动降低了海马星形胶质细胞和髓鞘衰老的标记物，但增加了血管生成的标记物血管内皮生长因子。脑血管铸型显示运动诱导的结构改变与外周血管内皮细胞功能的改善有关。我们的结果表明，久坐不动的生活方式和伴随的血管功能下降会加剧与年龄相关的星形胶质细胞肥大/反应和髓鞘失调。然而，这些影响似乎是可逆的，从中年开始锻炼。由于这段寿命与大脑老化的多个标志的出现相吻合，包括认知能力下降的初步迹象，这可能是一个干预的机会之窗，因为大脑似乎仍具有显著的血管可塑性。这些结果也可能对老年女性有特殊的影响，她们比男性更容易受到某些导致血管老化的危险因素的影响。
Healthy brain aging and cognitive function are promoted by exercise. The benefits of exercise are attributed to several mechanisms, many which highlight its neuroprotective role via actions that enhance neurogenesis, neuronal morphology and/or neurotrophin release. However, the brain is also composed of glial and vascular elements, and comparatively less is known regarding the effects of exercise on these components in the aging brain. Here, we show that aerobic exercise at mid-age decreased markers of unhealthy brain aging including astrocyte hypertrophy, a hallmark of brain aging. Middle-aged female mice were assigned to a sedentary group or provided a running wheel for six weeks. Exercise decreased hippocampal astrocyte and myelin markers of aging but increased VEGF, a marker of angiogenesis. Brain vascular casts revealed exercise-induced structural modifications associated with improved endothelial function in the periphery. Our results suggest that age-related astrocyte hypertrophy/reactivity and myelin dysregulation are aggravated by a sedentary lifestyle and accompanying reductions in vascular function. However, these effects appear reversible with exercise initiated at mid-age. As this period of the lifespan coincides with the appearance of multiple markers of brain aging, including initial signs of cognitive decline, it may represent a window of opportunity for intervention as the brain appears to still possess significant vascular plasticity. These results may also have particular implications for aging females who are more susceptible than males to certain risk factors which contribute to vascular aging.
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影响因子：
3.7
作者：
Lachman, Margie E.;Agrigoroaei, Stefan
通讯作者：
Agrigoroaei, Stefan
影响因子：
--
作者：
GEINISMAN, Y;BONDAREFF, W;DODGE, JT
通讯作者：
DODGE, JT
影响因子：
8.3
作者：
Arribas, SM;Hillier, C;McGrath, JC
通讯作者：
McGrath, JC
影响因子：
4.2
作者：
HANSEN, LA;ARMSTRONG, DM;TERRY, RD
通讯作者：
TERRY, RD
DOI：
10.1093/geronj/32.1.3
发表时间：
1977-01-01
期刊：
JOURNALS OF GERONTOLOGY
影响因子：
--
作者：
LANDFIELD, PW;ROSE, G;LYNCH, G
通讯作者：
LYNCH, G