Does clinically measured walking capacity contribute to real-world walking performance in Parkinson's disease?
Does clinically measured walking capacity contribute to real-world walking performance in Parkinson's disease?
复制标题
DOI：
10.1016/j.parkreldis.2022.11.016
复制
发表时间：
2022-12
影响因子：
4.1
通讯作者：
Ellis, Terry D.
中科院分区：
文献类型：
--
作者：
Zajac, Jenna A.;Cavanaugh, James T.;Baker, Teresa;Duncan, Ryan P.;Fulford, Daniel;Girnis, Jaimie;LaValley, Michael;Nordahl, Timothy;Porciuncula, Franchino;Rawson, Kerri S.;Saint -Hilaire, Marie;Thomas, Cathi A.;Earhart, Gammon M.;Ellis, Terry D.
该研究探讨了临床测量的步行能力如何有助于帕金森病（PD）患者的真实行走表现。分析了来自PD临床试验的横断面基线数据（n=82）。6分钟步行试验（6 MWT）和10米步行试验（10 MWT）分别用于产生步行耐力和快速步态速度的能力指标。使用佩戴七天的活动监测器来生成平均每日步数和每周中等强度步行分钟数的性能指标。单变量线性回归分析被用来检查每个容量和性能指标之间的关联，在全样本和更少和更活跃的亚组。步行能力对全样本（耐力：R2= 0.13，p<0.001;快速步态速度：R2= 0.07，p= 0.017）和活动较少亚组（耐力：R2= 0.09，p= 0.045）的每日步数有显著贡献。同样，步行能力在全样本（耐力：R2= 0.13，p<0.001;快速步态速度：R2= 0.09，p= 0.007）和较少活动亚组（耐力：R2= 0.25，p<0.001;快速步态速度：R2= 0.21，p= 0.007）中对每周中等强度分钟数有显著贡献。在更活跃的亚组中，步行能力对每日步数或中等强度分钟数没有显著贡献。步行能力的贡献，但解释了相对较小的一部分，在现实世界中的步行性能的变化。在不太活跃的个体中，这种贡献稍大。这项研究增加了对临床测量的步行能力可能对了解PD患者的真实步行能力的益处有限的观点的支持。步行能力之外的因素可能更好地解释实际的步行行为。
The study examined how clinically measured walking capacity contributes to real-world walking performance in persons with Parkinson’s disease (PD). Cross-sectional baseline data (n=82) from a PD clinical trial were analyzed. The 6-Minute Walk Test (6MWT) and 10-Meter Walk Test (10MWT) were used to generate capacity metrics of walking endurance and fast gait speed, respectively. An activity monitor worn for seven days was used to generate performance metrics of mean daily steps and weekly moderate intensity walking minutes. Univariate linear regression analyses were used to examine associations between each capacity and performance measure in the full sample and less and more active subgroups. Walking capacity significantly contributed to daily steps in the full sample (endurance: R2=.13, p<.001; fast gait speed: R2=.07, p=.017) and in the less active subgroup (endurance: R2=.09, p=.045). Similarly, walking capacity significantly contributed to weekly moderate intensity minutes in the full sample (endurance: R2=.13, p<.001; fast gait speed: R2=.09, p=.007) and less active subgroup (endurance: R2= .25, p<.001; fast gait speed: R2=.21, p=.007). Walking capacity did not significantly contribute to daily steps or moderate intensity minutes in the more active subgroup. Walking capacity contributed to, but explained a relatively small portion of the variance in, real-world walking performance. The contribution was somewhat greater in less active individuals. The study adds support to the idea that clinically measured walking capacity may have limited benefit for understanding real-world walking performance in PD. Factors beyond walking capacity may better account for actual walking behavior.
登录
查看更多内容
DOI：
10.1249/mss.0b013e31817c7133
发表时间：
2008-07-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Tudor-Locke, Catrine;Hatano, Yoshiro;Kang, Minsoo
通讯作者：
Kang, Minsoo
DOI：
10.1097/npt.0b013e318254ba7a
发表时间：
2012-06
期刊：
Journal of neurologic physical therapy : JNPT
影响因子：
--
作者：
Cavanaugh JT;Ellis TD;Earhart GM;Ford MP;Foreman KB;Dibble LE
通讯作者：
Dibble LE
DOI：
10.1038/s41531-021-00171-0
发表时间：
2021-03-05
期刊：
NPJ Parkinson's disease
影响因子：
--
作者：
Atrsaei A;Corrà MF;Dadashi F;Vila-Chã N;Maia L;Mariani B;Maetzler W;Aminian K
通讯作者：
Aminian K
影响因子：
8.6
作者：
Shulman, Lisa M.
通讯作者：
Shulman, Lisa M.
帕金森病的运动自动化。
影响因子：
6.1
作者：
Wu T;Hallett M;Chan P
通讯作者：
Chan P