The complexities of malaria disease manifestations with a focus on asymptomatic malaria.
The complexities of malaria disease manifestations with a focus on asymptomatic malaria.
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DOI：
10.1186/1475-2875-11-29
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发表时间：
2012-01-31
期刊：
影响因子：
3
通讯作者：
Joshi H
中科院分区：
文献类型：
--
作者：
Laishram DD;Sutton PL;Nanda N;Sharma VL;Sobti RC;Carlton JM;Joshi H
疟疾是发展中国家的一种严重寄生虫病，发病率和死亡率都很高。疟疾的发病机制复杂，临床表现从重而复杂，到轻而不复杂，再到无症状的疟疾。尽管对疾病的临床严重性进行了大量研究，但对无症状疟疾感染的了解仍然很少。无症状疟疾仍然是疟疾控制方案的一个挑战，因为它严重影响传播动态。需要对宿主和寄生虫之间在不同临床结局发展过程中的相互作用有透彻的了解。本文就无症状疟疾研究和防治中存在的问题和障碍进行了讨论。描述了与不同临床结果相关的人类和寄生虫因素，并概述了控制疾病的管理和治疗策略。此外，还强调了在无症状疟疾知识方面的重大差距，这些差距应成为今后制定更有效的疟疾控制战略研究的重点。
Malaria is a serious parasitic disease in the developing world, causing high morbidity and mortality. The pathogenesis of malaria is complex, and the clinical presentation of disease ranges from severe and complicated, to mild and uncomplicated, to asymptomatic malaria. Despite a wealth of studies on the clinical severity of disease, asymptomatic malaria infections are still poorly understood. Asymptomatic malaria remains a challenge for malaria control programs as it significantly influences transmission dynamics. A thorough understanding of the interaction between hosts and parasites in the development of different clinical outcomes is required. In this review, the problems and obstacles to the study and control of asymptomatic malaria are discussed. The human and parasite factors associated with differential clinical outcomes are described and the management and treatment strategies for the control of the disease are outlined. Further, the crucial gaps in the knowledge of asymptomatic malaria that should be the focus of future research towards development of more effective malaria control strategies are highlighted.
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