Biodegradable Polyphosphazenes for Regenerative Engineering.

Biodegradable Polyphosphazenes for Regenerative Engineering.
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DOI:
10.1557/s43578-022-00551-z
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发表时间:
2022-04
影响因子:
2.7
通讯作者:
Laurencin, Cato T.
Laurencin, Cato T.
中科院分区:
材料科学4区
文献类型:
--
作者:
Chen, Feiyang;Teniola, Oyindamola R.;Laurencin, Cato T.

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再生工程是一个寻求再生复杂组织和生物系统的领域,而不是简单地恢复和修复单个组织或器官。自2012年首次引入再生工程以来,大量研究致力于该领域的发展。可生物降解的聚合物(例如聚磷腈)作为再生工程材料尤其引起了人们的极大兴趣,因为它们在设计成具有广泛机械性能、降解速率和化学功能的材料时具有合成灵活性。这些聚磷腈可以完全水解降解,并提供无害且pH中性的缓冲降解产物,例如磷酸盐和氨,这对于减少体内炎症至关重要。在这里,我们讨论聚磷腈的当前成就、合成它们的不同方法,以及它们在骨骼、神经和弹性组织等组织再生中的应用。
Regenerative engineering is a field that seeks to regenerate complex tissues and biological systems, rather than simply restore and repair individual tissues or organs. Since the first introduction of regenerative engineering in 2012, numerous research has been devoted to the development of this field. Biodegradable polymers such as polyphosphazenes in particular have drawn significant interest as regenerative engineering materials for their synthetic flexibility in designing into materials with a wide range of mechanical properties, degradation rates, and chemical functionality. These polyphosphazenes can go through complete hydrolytic degradation and provide harmlessly and pH neutral buffering degradation products such as phosphates and ammonia, which is crucial for reducing inflammation in vivo. Here, we discuss the current accomplishments of polyphosphazene, different methods for synthesizing them, and their applications in tissue regeneration such as bones, nerves, and elastic tissues.
生物启动的脚手架设计,用于再生肌肉骨骼组织界面。
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