Epidemic characteristics of hemorrhagic fever with renal syndrome in China, 2006-2012.
Epidemic characteristics of hemorrhagic fever with renal syndrome in China, 2006-2012.
复制标题
DOI：
10.1186/1471-2334-14-384
复制
发表时间：
2014-07-11
影响因子：
3.7
通讯作者：
Li D
中科院分区：
文献类型：
--
作者：
Zhang S;Wang S;Yin W;Liang M;Li J;Zhang Q;Feng Z;Li D
由汉坦病毒引起的肾综合征出血热是中国面临的严重公共卫生问题。2004年，中国疾控中心在网上建立了全国法定传染病监测系统，2005年将鼠类监测点调整为22个省的40个监测点。为了解中国地区肾综合征出血热(HFRS)近年来的流行趋势，对2006-2012年人间病例和鼠类宿主监测资料进行分析。对2006~2012年肾综合征出血热人间病例记录和鼠类宿主监测资料进行分析。为了更好地了解中国地区汉坦病毒的分子多样性，构建了58株汉坦病毒M片段全序列的系统发育树，并对其进行了分析。2006年至2012年共报告肾综合征出血热人间病例77558例，死亡866例，年均发病率为0.83例/10万人口，病死率为1.13%。84.16%的病例集中在9个省，主要集中在春季和秋冬季。男性肾综合征出血热发病率是女性的3倍以上，农民仍占最大比例。2006-2012年鼠类平均密度相对稳定。野外以黑线姬鼠为主，居民区以褐家鼠为主。2012年，汉坦病毒在啮齿动物中的携带率和感染率都有快速上升。进化树分析表明，中国体内至少有6个汉滩病毒分支和5个汉城病毒分支。中国地区肾综合征出血热仍是发病率和病死率较高的自然疫源地，其分布和流行趋势也发生了变化。为减少中国地区肾综合征出血热的感染，应完善和加强监测措施和防控策略。
Hemorrhagic fever with renal syndrome (HFRS) caused by hantaviruses is a serious public health problem in China. The National Notifiable Disease Surveillance System (NNDSS) was established online by China CDC in 2004 and rodent surveillance sites were adjusted to 40 sites in 22 provinces in 2005. Here we analyzed the surveillance data of both human cases and rodents host during 2006–2012 to examine the epidemic trends of HFRS in recent years in China. Records on HFRS human cases and surveillance data of rodents host from 2006 to 2012 were analyzed. Phylogenetic tree based on complete sequence of M segment of 58 virus isolates was constructed and analyzed to make a better understanding of the molecular diversity of hantaviruses in China. During 2006–2012, a total of 77558 HFRS human cases and 866 deaths were reported with the average annual incidence rate of 0.83 cases/100,000 population and case fatality rate of 1.13%. 84.16% of the total cases were clustered in 9 provinces and mainly reported in spring and autumn-winter seasons. HFRS incidence in males was over 3 times higher than in females and farmers still accounted for the largest proportion. The average density of rodents was relatively stable from 2006 to 2012. Apodemus agrarius and Rattus norvegicus were predominant in wild field and residential area, respectively. Both hantaviruses carrying and infection rates in rodents had a rapid increase in 2012. Phylogenetic analysis showed that at least six clades of Hantaan virus and five of Seoul virus were prevalent in China. HFRS in China was still a natural focal disease with relatively high morbidity and fatality and its distribution and epidemic trends had also changed. Surveillance measures, together with prevention and control strategies should be improved and strengthened to reduce HFRS infection in China.
登录
查看更多内容
影响因子：
6.4
作者：
CHEN, HX;QIU, FX;GAO, SY
通讯作者：
GAO, SY
影响因子：
4.6
作者：
Ulrich, R;Hjelle, B;Krüger, DH
通讯作者：
Krüger, DH
影响因子：
3.7
作者：
Fang, Liqun;Yan, Lei;Liang, Song;de Vlas, Sake J.;Feng, Dan;Han, Xiaona;Zhao, Wenjuan;Xu, Bing;Bian, Ling;Yang, Hong;Gong, Peng;Richardus, Jan Hendrik;Cao, Wuchun
通讯作者：
Cao, Wuchun
影响因子：
6.4
作者：
LEE, HW;BAEK, LJ;JOHNSON, KM
通讯作者：
JOHNSON, KM
影响因子：
12.7
作者：
Zou, Yang;Hu, Jing;Zhang, Yong-Zhen
通讯作者：
Zhang, Yong-Zhen