Pregnancy Alters Renal and Blood Burden of Mercury in Females.
Pregnancy Alters Renal and Blood Burden of Mercury in Females.
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DOI:
10.1007/s12011-018-1278-1
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发表时间:
2018-11
影响因子:
3.9
通讯作者:
Bridges CC
中科院分区:
文献类型:
--
作者:
Orr SE;Franklin RC;George HS;Nijhara S;Joshee L;Bridges CC
Methylmercury (CH3Hg+), a common environmental toxicant, has serious detrimental effects in numerous organ systems. We hypothesize that a significant physiological change, like pregnancy, can alter the disposition and accumulation of mercury. To test this hypothesis, pregnant and non-pregnant female Wistar rats were exposed orally to CH3Hg+. The amount of mercury in blood and total renal mass was significantly lower in pregnant rats than in non-pregnant rats. This finding may be due to expansion of plasma volume in pregnant rats and dilution of mercury, leading to lower levels of mercury in maternal blood and kidneys.
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