Childhood incident asthma and traffic-related air pollution at home and school.
Childhood incident asthma and traffic-related air pollution at home and school.
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DOI：
10.1289/ehp.0901232
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发表时间：
2010-07
影响因子：
10.4
通讯作者：
Berhane K
中科院分区：
文献类型：
--
作者：
McConnell R;Islam T;Shankardass K;Jerrett M;Lurmann F;Gilliland F;Gauderman J;Avol E;Künzli N;Yao L;Peters J;Berhane K
与农药有关的空气污染与心肺功能不良影响有关，包括哮喘发病率增加。然而，关于学校交通暴露对新发哮喘的影响的研究很少。我们评估了新发哮喘与家庭和学校附近交通相关污染的关系。在对2，497名幼儿园和一年级儿童的3年随访期间，确定了父母报告的新发哮喘（n = 120）的医生诊断，这些儿童在进入南加州儿童健康研究时没有哮喘和喘息。我们根据交通量、离家和学校的距离以及当地气象的线源扩散模型评估了与交通相关的污染暴露。区域环境臭氧，二氧化氮（NO2）和颗粒物连续测量在一个中央站点监测在每个13个研究社区。新发哮喘的危险比（HR）按环境中心污染物的范围和每个交通暴露指标的居民四分位数范围进行缩放。哮喘风险随着来自住家附近道路[HR 1.51; 95%置信区间（CI），1.25-1.82]和学校附近道路（HR 1.45; 95% CI，1.06-1.98）的模拟交通相关污染暴露而增加。在每个社区的中心站点测量的环境NO2也与风险增加相关（HR 2.18; 95%CI，1.18-4.01）。在NO2和模拟交通暴露的模型中，哮喘与学校和家庭的交通相关污染存在独立相关性，而NO2的估计值则有所减弱（HR 1.37; 95%CI，0.69-2.71）。在学校和家中暴露于与空气污染有关的污染物都可能导致哮喘的发生。
Traffic-related air pollution has been associated with adverse cardiorespiratory effects, including increased asthma prevalence. However, there has been little study of effects of traffic exposure at school on new-onset asthma. We evaluated the relationship of new-onset asthma with traffic-related pollution near homes and schools. Parent-reported physician diagnosis of new-onset asthma (n = 120) was identified during 3 years of follow-up of a cohort of 2,497 kindergarten and first-grade children who were asthma- and wheezing-free at study entry into the Southern California Children’s Health Study. We assessed traffic-related pollution exposure based on a line source dispersion model of traffic volume, distance from home and school, and local meteorology. Regional ambient ozone, nitrogen dioxide (NO2), and particulate matter were measured continuously at one central site monitor in each of 13 study communities. Hazard ratios (HRs) for new-onset asthma were scaled to the range of ambient central site pollutants and to the residential interquartile range for each traffic exposure metric. Asthma risk increased with modeled traffic-related pollution exposure from roadways near homes [HR 1.51; 95% confidence interval (CI), 1.25–1.82] and near schools (HR 1.45; 95% CI, 1.06–1.98). Ambient NO2 measured at a central site in each community was also associated with increased risk (HR 2.18; 95% CI, 1.18–4.01). In models with both NO2 and modeled traffic exposures, there were independent associations of asthma with traffic-related pollution at school and home, whereas the estimate for NO2 was attenuated (HR 1.37; 95% CI, 0.69–2.71). Traffic-related pollution exposure at school and homes may both contribute to the development of asthma.
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影响因子：
10.4
作者：
Green RS;Smorodinsky S;Kim JJ;McLaughlin R;Ostro B
通讯作者：
Ostro B
影响因子：
9.8
作者：
Briggs, DJ;de Hoogh, C;Smallbone, K
通讯作者：
Smallbone, K
影响因子：
10.4
作者：
McConnell R;Berhane K;Yao L;Jerrett M;Lurmann F;Gilliland F;Künzli N;Gauderman J;Avol E;Thomas D;Peters J
通讯作者：
Peters J
DOI：
10.1164/rccm.200906-0858oc
发表时间：
2010-03-15
影响因子：
24.7
作者：
Gehring, Ulrike;Wijga, Alet H.;Brunekreef, Bert
通讯作者：
Brunekreef, Bert
DOI：
10.1164/rccm.200706-863oc
发表时间：
2008-02-15
影响因子：
24.7
作者：
Islam, Talat;McConnell, Rob;Gilliland, Frank D.
通讯作者：
Gilliland, Frank D.