The Digital Ageing Atlas: integrating the diversity of age-related changes into a unified resource.
The Digital Ageing Atlas: integrating the diversity of age-related changes into a unified resource.
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DOI：
10.1093/nar/gku843
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发表时间：
2015-01
影响因子：
14.9
通讯作者：
de Magalhães JP
中科院分区：
文献类型：
--
作者：
Craig T;Smelick C;Tacutu R;Wuttke D;Wood SH;Stanley H;Janssens G;Savitskaya E;Moskalev A;Arking R;de Magalhães JP
几十年来，已经进行了表征人类衰老表型的多项研究。然而，没有集中的资源来整理与年龄有关的多种变化的数据。目前，研究人员必须查阅几个来源，包括主要出版物，以获得各级与年龄有关的数据。为了解决这个问题，并促进综合，系统级的老龄化研究，我们开发了数字老龄化地图集（DAA）。DAA是一个一站式收集人类年龄相关数据的平台，涵盖不同的生物层面（分子、细胞、生理、心理和病理），可在网上免费获取（http：//ageing-map.org/）。>3000个与年龄相关的变化中的每一个都与特定组织相关联，并且有自己的页面显示各种信息，包括至少一个参考文献。与XML相关的更改也可以在层次树中相互链接，以表示不同类型的关系。此外，我们开发了一个直观和用户友好的界面，允许搜索，浏览和检索信息的综合和互动的方式。总的来说，DAA提供了一种新的方法来系统化老龄化资源，提供了一个手动策划和易于访问的与年龄有关的变化来源。
Multiple studies characterizing the human ageing phenotype have been conducted for decades. However, there is no centralized resource in which data on multiple age-related changes are collated. Currently, researchers must consult several sources, including primary publications, in order to obtain age-related data at various levels. To address this and facilitate integrative, system-level studies of ageing we developed the Digital Ageing Atlas (DAA). The DAA is a one-stop collection of human age-related data covering different biological levels (molecular, cellular, physiological, psychological and pathological) that is freely available online (http://ageing-map.org/). Each of the >3000 age-related changes is associated with a specific tissue and has its own page displaying a variety of information, including at least one reference. Age-related changes can also be linked to each other in hierarchical trees to represent different types of relationships. In addition, we developed an intuitive and user-friendly interface that allows searching, browsing and retrieving information in an integrated and interactive fashion. Overall, the DAA offers a new approach to systemizing ageing resources, providing a manually-curated and readily accessible source of age-related changes.
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影响因子：
14.9
作者：
Sunkin SM;Ng L;Lau C;Dolbeare T;Gilbert TL;Thompson CL;Hawrylycz M;Dang C
通讯作者：
Dang C
DOI：
10.1098/rstb.2010.0275
发表时间：
2011-01-12
影响因子：
6.3
作者：
Kirkwood, Thomas B. L.
通讯作者：
Kirkwood, Thomas B. L.
影响因子：
4.6
作者：
Welle, S;Brooks, AI;Thornton, CA
通讯作者：
Thornton, CA
影响因子：
14.9
作者：
Gremse M;Chang A;Schomburg I;Grote A;Scheer M;Ebeling C;Schomburg D
通讯作者：
Schomburg D
影响因子：
5.8
作者：
Tao, Y;Friedman, C;Lussier, YA
通讯作者：
Lussier, YA