Human monkeypox outbreak caused by novel virus belonging to Congo Basin clade, Sudan, 2005.
Human monkeypox outbreak caused by novel virus belonging to Congo Basin clade, Sudan, 2005.
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DOI：
10.3201/eid1610.100713
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发表时间：
2010-10
影响因子：
11.8
通讯作者：
Abdalla MS
中科院分区：
文献类型：
--
作者：
Formenty P;Muntasir MO;Damon I;Chowdhary V;Opoka ML;Monimart C;Mutasim EM;Manuguerra JC;Davidson WB;Karem KL;Cabeza J;Wang S;Malik MR;Durand T;Khalid A;Rioton T;Kuong-Ruay A;Babiker AA;Karsani ME;Abdalla MS
TOC摘要：这种病毒应该被认为是苏丹联合州本提乌湿地地区的地方性疾病。为了确定2005年11月苏丹联合州猴痘病毒(MPXV)感染的暴发源，我们进行了一项回顾性调查。MPXV是在萨赫勒大草原下的环境中发现的。使用了三种病例通知类别：疑似病例、可能病例和确诊病例。分子、病毒学和血清学分析用于检测血液标本、水泡拭子和从有症状和恢复者身上获得的结皮标本。2005年9月至12月期间报告了10例实验室确诊病例和9例MPXV疑似病例；没有死亡病例。描述了长达5代的人与人之间的传播。我们的调查不能完全确定疫情的源头。初步数据表明，此次暴发期间分离到的MPXV毒株是属于刚果盆地分支的一种新病毒。我们的结果表明，MPXV应该被认为是联合州湿地地区特有的。这一发现将加强对该病毒生态位的理解。
TOC Summary: This virus should be considered endemic to the wetland areas of Bentiu, Unity State, Sudan. To determine the outbreak source of monkeypox virus (MPXV) infections in Unity State, Sudan, in November 2005, we conducted a retrospective investigation. MPXV was identified in a sub-Sahelian savannah environment. Three case notification categories were used: suspected, probable, and confirmed. Molecular, virologic, and serologic assays were used to test blood specimens, vesicular swabs, and crust specimens obtained from symptomatic and recovering persons. Ten laboratory-confirmed cases and 9 probable cases of MPXV were reported during September–December 2005; no deaths occurred. Human-to-human transmission up to 5 generations was described. Our investigation could not fully determine the source of the outbreak. Preliminary data indicate that the MPXV strain isolated during this outbreak was a novel virus belonging to the Congo Basin clade. Our results indicate that MPXV should be considered endemic to the wetland areas of Unity State. This finding will enhance understanding of the ecologic niche for this virus.
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影响因子：
9.4
作者：
Meyer, H;Perrichot, M;Formenty, P
通讯作者：
Formenty, P
影响因子：
9.4
作者：
Loparev, VN;McCaustland, K;Schmid, DS
通讯作者：
Schmid, DS
影响因子：
3.7
作者：
Levine RS;Peterson AT;Yorita KL;Carroll D;Damon IK;Reynolds MG
通讯作者：
Reynolds MG
影响因子：
6.7
作者：
Heymann, DL;Szczeniowski, M;Esteves, K
通讯作者：
Esteves, K
影响因子：
3.7
作者：
Chen, NH;Li, GY;Liszewski, MK;Atkinson, JP;Jahrling, PB;Feng, ZH;Schriewer, J;Buck, C;Wang, CL;Lefkowitz, EJ;Esposito, JJ;Harms, T;Damon, IK;Roper, RL;Upton, C;Buller, RML
通讯作者：
Buller, RML