Heparan Sulfate: A Regulator of White Adipocyte Differentiation and of Vascular/Adipocyte Interactions.
Heparan Sulfate: A Regulator of White Adipocyte Differentiation and of Vascular/Adipocyte Interactions.
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DOI：
10.3390/biomedicines10092115
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发表时间：
2022-08-29
期刊：
影响因子：
4.7
通讯作者：
中科院分区：
文献类型：
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作者：
White adipose tissues are major endocrine organs that release factors, termed adipokines, which affect other major organ systems. The development and functions of adipose tissues depend largely upon the glycosaminoglycan heparan sulfate. Heparan sulfate proteoglycans (HSPGs) surround both adipocytes and vascular structures and facilitate the communication between these two components. This communication mediates the continued export of adipokines from adipose tissues. Heparan sulfates regulate cellular physiology and communication through a sulfation code that ionically interacts with heparan-binding regions on a select set of proteins. Many of these proteins are growth factors and chemokines that regulate tissue function and inflammation. Cells regulate heparan sulfate sulfation through the release of heparanases and sulfatases. It is now possible to tissue engineer vascularized adipose tissues that express heparan sulfate proteoglycans. This makes it possible to use these tissue constructs to study the role of heparan sulfates in the regulation of adipokine production and release. It is possible to regulate the production of heparanases and sulfatases in order to fine-tune experimental studies.
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影响因子：
5.6
作者：
Berthod, F;Germain, L;Auger, FA
通讯作者：
Auger, FA
影响因子：
120.1
作者：
Cao, Yihai
通讯作者：
Cao, Yihai
DOI：
10.1073/pnas.0601752103
发表时间：
2006-04-25
影响因子：
11.1
作者：
Gesta, S;Blüher, M;Kahn, CR
通讯作者：
Kahn, CR
影响因子：
20.3
作者：
Axelsson, Jakob;Xu, Ding;Esko, Jeffrey D.
通讯作者：
Esko, Jeffrey D.
影响因子：
--
作者：
Borges, J;Mueller, MC;Stark, GB
通讯作者：
Stark, GB