Two-Mode Models of Self-Regulation as a Tool for Conceptualizing Effects of the Serotonin System in Normal Behavior and Diverse Disorders.
Two-Mode Models of Self-Regulation as a Tool for Conceptualizing Effects of the Serotonin System in Normal Behavior and Diverse Disorders.
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DOI：
10.1111/j.1467-8721.2009.01635.x
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发表时间：
2009-08-01
影响因子：
7.2
通讯作者：
Joormann J
中科院分区：
文献类型：
--
作者：
Carver CS;Johnson SL;Joormann J
5-羟色胺系统是一组神经通路，其整体功能水平（从低到高）与各种心理和行为变异有关。肾上腺素能功能的个体差异在人格和对心理障碍的脆弱性方面都很重要。这些障碍的范围很广从冲动攻击到抑郁。理解这种对多巴胺能功能差异的不同反映的一种方法是通过自我调节的双模式（或双过程）模型的透镜来观察多巴胺能功能。这些理论包括一个对当下的联想线索快速反应的低阶系统和一个反射性和计划性反应的高阶系统。低能量函数似乎增强了低阶系统的影响。这往往会产生冲动的反应。那么，为什么低β-肾上腺素能功能也与以嗜睡和反应迟钝为特征的抑郁症有关呢？答案肯定是，较低系统的提升与其他因素相互作用。一种假设是，低的多巴胺能功能加上对激励的高敏感性产生对冲动方法的脆弱性，而低多巴胺能功能加上低激励敏感性产生对抑郁的脆弱性。以这种方式概念化多巴胺能功能有助于将与非常不同的疾病有关的信息整合到一个连贯的画面中。
The serotonin system is a collection of neural pathways whose overall level of functioning (from low to high) relates to diverse kinds of psychological and behavioral variability. Individual differences in serotonergic function are important both in personality and in vulnerability to psychological disorders. These disorders range widely—from impulsive aggression to depression. One way to understand such diverse reflections of differences in serotonergic function is by viewing serotonergic function through the lens of two-mode (or dual-process) models of self-regulation. Such theories posit a lower-order system that responds quickly to associative cues of the moment and a higher-order system that responds reflectively and planfully. Low serotonergic function appears to enhance influence of the lower-order system. This often yields impulsive reactivity. Why, then, does low serotonergic function also relate to depression, which is characterized by lethargy and unresponsiveness? The answer must be that ascendance of the lower system interacts with other factors. One hypothesis is that low serotonergic function plus high sensitivity to incentives yields vulnerability to impulsive approach, whereas low serotonergic function plus low incentive sensitivity yields vulnerability to depression. Conceptualizing serotonergic function this way helps integrate information pertaining to very different disorders into a coherent picture.
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DOI：
10.1111/j.1467-8721.2008.00599.x
发表时间：
2008-10-01
影响因子：
7.2
作者：
Raine, Adrian
通讯作者：
Raine, Adrian
影响因子：
22.4
作者：
Carver, Charles S.;Johnson, Sheri L.;Joormann, Jutta
通讯作者：
Joormann, Jutta
DOI：
10.1111/j.1467-8721.2008.00594.x
发表时间：
2008-10-01
影响因子：
7.2
作者：
Harvey, Allison G.
通讯作者：
Harvey, Allison G.
影响因子：
5.9
作者：
Depue, RA
通讯作者：
Depue, RA
影响因子：
16.4
作者：
EPSTEIN, S
通讯作者：
EPSTEIN, S