Genetic mapping using 1.4M SNP array refined loci for fatty acid composition traits in Chinese Erhualian and Bamaxiang pigs
Genetic mapping using 1.4M SNP array refined loci for fatty acid composition traits in Chinese Erhualian and Bamaxiang pigs
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利用 1.4M SNP 阵列精化位点对中国二花莲和八马香猪脂肪酸组成性状进行遗传作图
DOI：
10.1111/jbg.12297
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发表时间：
2017-09
影响因子：
2.6
通讯作者：
Yang B
中科院分区：
文献类型：
--
作者：
Zhang J;Zhang Y;Gong H;Cui L;Huang T;Ai H;Ren J;Huang L;Yang B
中国地方猪与西方商品猪相比，表现出显著的遗传和表型差异。本研究基于定制的140万个SNP芯片，对中国二花脸猪（n = 331）和八马乡猪（n = 315）的660K SNP与背最长肌脂肪酸组成性状的相关性进行了研究。在p值阈值为1 × 10−6时，我们确定了20个脂肪酸组成性状的64个显著关联，其中42个与先前报道的基因座处于低连锁不平衡（r2.2）的关联被认为是新的。我们大大提高了先前检测到的FADS2、FADVL7、FADVL6和FADS3基因附近的四个位点的关联强度和精确度，促进了后续候选基因研究。此外，我们还确定了ABCD 2、ACSBG 1、HPGDS、DAGT 2、ACAD 10和ACSL 1基因附近的与脂肪酸代谢相关的功能位点。本研究在二花脸猪和八马乡猪中鉴定了与脂肪酸组成性状相关的有价值的遗传变异和候选基因。部分位点可用于猪的营养改良。利用高标记密度和低确定偏倚的SNP芯片提高了中国地方猪QTL检测的效率和精度。
SummaryChinese indigenous pigs display marked genetic and phenotypic differences compared with western commercial pigs. In this study, we tested the association between 660K SNPs and longissimus muscle fatty acid composition traits in Chinese Erhualian (n = 331) and Bamaxiang (n = 315) pigs based on a customized 1.4 million SNP array. We identified a total of 64 significant associations for 20 fatty acid composition traits at the p‐value threshold of 1 × 10−6 among which 42 associations in low linkage disequilibrium (r2 .2) with previously reported loci were considered novel. We substantially improved the strength and precision of the associations at four previously detected loci near FADS2, ELOVL7, ELOVL6 and FASN genes, facilitating follow‐up candidate gene studies. Moreover, we also identified loci near ABCD2, ACSBG1, ELOVL5, HPGDS, DAGT2, ACAD10 and ACSL1 genes with function relevant to metabolism of fatty acids. In this study, valuable genetic variants and candidate genes associated with fatty acid composition traits were identified in Erhualian and Bamaxiang pigs. Some identified loci could be used to improve pork nutrition in pig breeding practice. Using the SNP array with higher marker density and less ascertainment bias improved QTL detection power and precision in Chinese indigenous pigs.
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影响因子：
3.7
作者：
Corominas J;Ramayo-Caldas Y;Puig-Oliveras A;Pérez-Montarelo D;Noguera JL;Folch JM;Ballester M
通讯作者：
Ballester M
影响因子：
30.8
作者：
Zhou, Xiang;Stephens, Matthew
通讯作者：
Stephens, Matthew
全基因组 SNP 标记揭示中国和西方猪的遗传多样性、连锁不平衡和选择特征
影响因子：
3.7
作者：
Ai H;Huang L;Ren J
通讯作者：
Ren J
影响因子：
64.8
作者：
通讯作者：
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FADS基因的变体与加拿大荷斯坦奶牛的Omega-3和Omega-6牛奶脂肪酸之间的关联。
影响因子：
2.9
作者：
Ibeagha-Awemu EM;Akwanji KA;Beaudoin F;Zhao X
通讯作者：
Zhao X