Acoustoelectric imaging of deep dipoles in a human head phantom for guiding treatment of epilepsy.
Acoustoelectric imaging of deep dipoles in a human head phantom for guiding treatment of epilepsy.
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DOI：
10.1088/1741-2552/abb63a
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发表时间：
2020-10-30
影响因子：
4
通讯作者：
Witte RS
中科院分区：
文献类型：
--
作者：
Barragan A;Preston C;Alvarez A;Bera T;Qin Y;Weinand M;Kasoff W;Witte RS
本研究采用一个具有真实的颅骨的人头模型来证明经颅声电脑成像（tABI）作为一种新的模式在癫痫治疗过程中对深部偶极子源进行电标测的可行性，其分辨率和准确性远远优于传统的标测方法。该技术利用聚焦超声（US）束和组织电阻率之间的相互作用，以高空间分辨率（1至4 mm）定位深至63 mm的电流源密度，并以亚ms精度解析快速时变电流。在生物安全的US强度下，通过人类颅骨厚段的检测阈值低于0.5 mA，并且在人类大脑产生的强电流范围内。这项工作表明，4D tABI可能成为一种革命性的方式，用于实时高分辨率映射神经元电流，用于监测，分期和指导癫痫和其他以异常节律为特征的脑部疾病的治疗。
This study employs a human head model with real skull to demonstrate the feasibility of transcranial acoustoelectric brain imaging (tABI) as a new modality for electrical mapping of deep dipole sources during treatment of epilepsy with much better resolution and accuracy than conventional mapping methods. This technique exploits an interaction between a focused ultrasound (US) beam and tissue resistivity to localize current source densities as deep as 63 mm at high spatial resolution (1 to 4 mm) and resolve fast time-varying currents with sub-ms precision. Detection thresholds through a thick segment of the human skull at biologically safe US intensities was below 0.5 mA and within range of strong currents generated by the human brain. This work suggests that 4D tABI may emerge as a revolutionary modality for real-time high-resolution mapping of neuronal currents for the purpose of monitoring, staging, and guiding treatment of epilepsy and other brain disorders characterized by abnormal rhythms.
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影响因子：
16.6
作者：
Martinet LE;Fiddyment G;Madsen JR;Eskandar EN;Truccolo W;Eden UT;Cash SS;Kramer MA
通讯作者：
Kramer MA
DOI：
10.1186/s40349-015-0030-y
发表时间：
2015
期刊：
Journal of therapeutic ultrasound
影响因子：
--
作者：
Farrer AI;Odéen H;de Bever J;Coats B;Parker DL;Payne A;Christensen DA
通讯作者：
Christensen DA
影响因子：
4.6
作者：
Kang, Xuan;Boly, Melanie;Struck, Aaron F.
通讯作者：
Struck, Aaron F.
影响因子：
4
作者：
Wang, Z. H.;Olafsson, R.;Witte, R. S.
通讯作者：
Witte, R. S.
DOI：
10.1016/j.msec.2012.07.024
发表时间：
2012-12-01
影响因子：
7.9
作者：
Kandadai, Madhuvanthi A.;Raymond, Jason L.;Shaw, George J.
通讯作者：
Shaw, George J.