Temporal clustering, tissue composition, and total variation for mapping oxygen extraction fraction using QSM and quantitative BOLD.
Temporal clustering, tissue composition, and total variation for mapping oxygen extraction fraction using QSM and quantitative BOLD.
复制标题
使用QSM和定量BOLD的时间聚类，组织组成和映射氧气萃取分数的总变化。
DOI：
10.1002/mrm.28875
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发表时间：
2021-11
影响因子：
3.3
通讯作者：
Wang, Yi
中科院分区：
文献类型：
--
作者：
Cho, Junghun;Spincemaille, Pascal;Nguyen, Thanh D.;Gupta, Ajay;Wang, Yi
关键词：
采用时间聚类、组织成分和总变异（CCTV），提高定量敏感性标测加定量血氧水平依赖性幅度（QSM+qBOLD或QQ）的氧提取分数（OEF）和脑氧代谢率（CMRO 2）标测的准确性。对11名健康受试者和33名缺血性卒中患者进行三维多回波梯度回波和动脉自旋标记成像。扩散加权成像（DWI）也获得了患者。CCTV映射是为了将组织类型信息整合到先前的时间演化聚类分析（CAT）和应用总变差（TV）的聚类中而开发的。使用CAT、CAT+TV（CATV）和建议的CCTV重建基于QQ的OEF和CMRO 2，并使用感兴趣区域分析、Kruskal-Wallis检验和事后Wilcoxson秩和检验对结果进行比较。在模拟中，CCTV比CAT或CATV提供更准确和精确的OEF。在健康受试者中，基于QQ的OEF与CCTV相比噪声更小，更均匀。在亚急性卒中患者中，与CAT或CATV相比，CCTV的OEF在DWI定义的病变与未受影响的对侧之间具有更大的对比度噪声比：1.9 ± 1.3 vs 1.1 ± 0.7（）vs 0.7 ± 0.5（）。CCTV映射显著提高了基于QQ的OEF对噪声的鲁棒性。
To improve the accuracy of quantitative susceptibility mapping plus quantitative blood oxygen level-dependent magnitude (QSM+qBOLD or QQ) based mapping of oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO2) using temporal clustering, tissue composition, and total variation (CCTV). Three-dimensional multi-echo gradient echo and arterial spin labeling images were acquired from 11 healthy subjects and 33 ischemic stroke patients. Diffusion-weighted imaging (DWI) was also obtained from patients. The CCTV mapping was developed for incorporating tissue-type information into clustering of the previous cluster analysis of time evolution (CAT) and applying total variation (TV). The QQ-based OEF and CMRO2 were reconstructed with CAT, CAT+TV (CATV), and the proposed CCTV, and results were compared using region-of-interest analysis, Kruskal-Wallis test, and post hoc Wilcoxson rank sum test. In simulation, CCTV provided more accurate and precise OEF than CAT or CATV. In healthy subjects, QQ-based OEF was less noisy and more uniform with CCTV than CAT. In subacute stroke patients, OEF with CCTV had a greater contrast-to-noise ratio between DWI-defined lesions and the unaffected contralateral side than with CAT or CATV: 1.9 ± 1.3 versus 1.1 ± 0.7 () versus 0.7 ± 0.5 (). The CCTV mapping significantly improves the robustness of QQ-based OEF against noise.
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影响因子：
3.7
作者：
Acosta-Cabronero J;Williams GB;Cardenas-Blanco A;Arnold RJ;Lupson V;Nestor PJ
通讯作者：
Nestor PJ
影响因子：
3.3
作者：
Cho J;Kee Y;Spincemaille P;Nguyen TD;Zhang J;Gupta A;Zhang S;Wang Y
通讯作者：
Wang Y
影响因子：
3.3
作者：
An, HY;Lin, WL
通讯作者：
Lin, WL
影响因子：
3.3
作者：
Cho J;Ma Y;Spincemaille P;Pike GB;Wang Y
通讯作者：
Wang Y
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y