Ivermectin: a complimentary weapon against the spread of malaria?
Ivermectin: a complimentary weapon against the spread of malaria?
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DOI：
10.1080/14787210.2017.1271713
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发表时间：
2017-03
影响因子：
5.7
通讯作者：
Foy BD
中科院分区：
文献类型：
--
作者：
Alout H;Foy BD
伊维菌素改变了寄生虫病的治疗方法，给人类和动物带来了不可估量的好处。伊维菌素在治疗几种被忽视的传染病方面是有效的，最近它已被证明可以减少疟疾寄生虫的传播。如果伊维菌素是一种长效制剂或重复给药，则加入伊维菌素可中断传播周期，从而使疟疾控制战略受益。反过来，这也将有助于控制被忽视的传染病，因为消除传染病的目标实现得较慢。尽管使用伊维菌素进行综合和持续的疾病控制具有相关性，但仍有一些关于安全性和实用性的基本问题有待解决。评估各种疟疾生态系统的效力以及药物或杀虫剂等控制工具之间的相互作用也很重要。几种传染病的重叠分布揭示了将针对几种传染病的控制方案整合到一个战略中以实现成本效益和消除目标的好处。使用伊维菌素控制疟疾传播将需要开发和测试长效制剂或重复治疗，将这些治疗与其他疾病控制工具一起实施可能会增加成功和持续控制的机会。
Ivermectin has transformed the treatment of parasitic diseases and led to incommensurable benefits to humans and animals. Ivermectin is effective in treating several neglected infectious diseases and recently it has been shown to reduce malaria parasite transmission. Malaria control strategies could benefit from the addition of ivermectin to interrupt the transmission cycle if it is a long lasting formulation or repeatedly administered. In turn, this will help also to control neglected infectious diseases where the elimination goal has been slower to achieve. Despite the relevance of using ivermectin for integrated and sustained disease control, there are still essential questions that remain to be addressed about safety and practicality. The efficacy in various malaria ecologies and the interaction between control tools, either drugs or insecticides, are also important to assess. Overlapping distribution of several infectious diseases reveals the benefit of integrating control programs against several infectious diseases into one strategy for cost effectiveness and to reach the elimination goals. The use of ivermectin to control malaria transmission will necessitate development and testing of long-lasting formulations or repeated treatments, and implementation of these treatments with other disease control tools may increase the chance of successful and sustained control.
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影响因子：
3.7
作者：
Harris, Caroline;Morlais, Isabelle;Cohuet, Anna
通讯作者：
Cohuet, Anna
影响因子：
3.2
作者：
Agarwala, S;Chen, W;Cook, TJ
通讯作者：
Cook, TJ
DOI：
10.1179/000349809x12459740922138
发表时间：
2009-09-01
影响因子：
--
作者：
Fritz, M. L.;Siegert, P. Y.;Miller, J. R.
通讯作者：
Miller, J. R.
DOI：
10.1093/infdis/jis184
发表时间：
2012-04-15
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
da Cruz FP;Martin C;Buchholz K;Lafuente-Monasterio MJ;Rodrigues T;Sönnichsen B;Moreira R;Gamo FJ;Marti M;Mota MM;Hannus M;Prudêncio M
通讯作者：
Prudêncio M
影响因子：
3
作者：
Chaccour CJ;Kobylinski KC;Bassat Q;Bousema T;Drakeley C;Alonso P;Foy BD
通讯作者：
Foy BD