Bioavailability and preliminary toxicity evaluations of alumina nanoparticles in vivo after oral exposure
Bioavailability and preliminary toxicity evaluations of alumina nanoparticles in vivo after oral exposure
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口服暴露后体内氧化铝纳米颗粒的生物利用度和初步毒性评估
DOI：
10.1039/c2tx20008b
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发表时间：
2012-07
影响因子：
2.1
通讯作者：
Haifang Wang
中科院分区：
文献类型：
--
作者：
Shengtao Yang;Tiancheng Wang;Erya Dong;Xinxin Chen;Kun Xiang;Jiahui Liu;Yuanfang Liu;Haifang Wang
氧化铝纳米颗粒是最重要的纳米材料之一，在各个领域都有着广泛的应用。在这项研究中，我们评估了氧化铝纳米颗粒在小鼠口服暴露后的生物利用度和毒性，与传统的氧化铝粉末相比。我们的研究结果表明，可以忽略不计的氧化铝纳米颗粒被吸收后曝光和氧化铝纳米颗粒不影响平衡的必需微量元素，包括铁，铜和锌。初步毒理学评价表明，氧化铝纳米颗粒的毒性较低。暴露于氧化铝纳米颗粒、氧化铝粉末和0.9%NaCl水溶液的小鼠的体重相似。血清生化指标无变化也表明毒性较低。与正在进行的安全性评价和应用的氧化铝纳米粒子的影响进行了讨论。
Alumina nanoparticles (NPs) are among the most important nanomaterials and are widely used in diverse areas. In this study, we evaluated the bioavailability and toxicity of alumina NPs in mice after oral exposure, compared with traditional alumina powder. Our results indicated that negligible alumina NPs were absorbed post-exposure and alumina NPs did not influence the balance of essential trace elements, including Fe, Cu and Zn. Preliminary toxicological evaluations suggested that alumina NPs were of low toxicity. The body weights were similar among the mice exposed to alumina NPs, alumina powder and 0.9% NaCl aqueous solution. The low toxicity was also indicated by the unchanged serum biochemical parameters. The implications related to the ongoing safety evaluations and applications of alumina NPs are discussed.
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影响因子：
8.9
作者：
Wang, Huanhua;Wick, Robert L.;Xing, Baoshan
通讯作者：
Xing, Baoshan
影响因子：
--
作者：
Sheng-Tao Yang;Jia-Hui Liu;Jing Wang;Yuan Yuan-Yuan;Aoneng Cao;Haifang Wang;Yuanfang Liu;Yuliang Zhao
通讯作者：
Sheng-Tao Yang;Jia-Hui Liu;Jing Wang;Yuan Yuan-Yuan;Aoneng Cao;Haifang Wang;Yuanfang Liu;Yuliang Zhao
影响因子：
3.4
作者：
R. Yokel
通讯作者：
R. Yokel
影响因子：
3.5
作者：
Wang, Jiangxue;Zhou, Guoqiang;Chai, Zhifang
通讯作者：
Chai, Zhifang
影响因子：
9.9
作者：
B. Paul;W. Martens;R. Frost
通讯作者：
B. Paul;W. Martens;R. Frost