Mechanisms involved in the intestinal absorption of dietary vitamin A and provitamin A carotenoids.
Mechanisms involved in the intestinal absorption of dietary vitamin A and provitamin A carotenoids.
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DOI：
10.1016/j.bbalip.2011.06.002
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发表时间：
2012-01
期刊：
影响因子：
--
通讯作者：
Harrison EH
中科院分区：
文献类型：
--
作者：
Harrison EH
维生素A是人体必需的营养素，并转化为视觉发色团，11-顺式-视黄醇，和激素，视黄酸。动物源性食物中的维生素A是以视黄醇的长链酰基酯的形式存在的，这些脂肪酸在被肠粘膜细胞吸收之前被消化为游离脂肪酸和视黄醇。然后，视黄醇再酯化为视黄酯，用于掺入胆色素微粒中，并通过脂质转运蛋白ABCA 1促进的消化吸收或流出到门静脉循环中。维生素原A类胡萝卜素如β-胡萝卜素存在于植物性食品中。这些和其它类胡萝卜素通过I型B类清道夫受体（SR-BI）转运到粘膜细胞中。维生素原A类胡萝卜素通过加氧酶和还原酶部分转化为视黄醇，并且如此产生的视黄醇可通过上述两种途径吸收。维生素A和类胡萝卜素肠道吸收的效率是由参与该过程的许多蛋白质的调节决定的。这些蛋白质的基因多态性导致维生素A和类胡萝卜素代谢和运输的个体差异。这篇文章是题为维甲酸和脂质代谢的特刊的一部分。
Vitamin A is an essential nutrient for humans and is converted to the visual chromophore, 11-cis-retinal, and to the hormone, retinoic acid. Vitamin A in animal-derived foods is found as long chain acyl esters of retinol and these are digested to free fatty acids and retinol before uptake by the intestinal mucosal cell. The retinol is then reesterified to retinyl esters for incorporation into chlylomicrons and absorbed via the lymphatics or effluxed into the portal circulation facilitated by the lipid transporter, ABCA1. Provitamin A carotenoids such as β-carotene are found in plant-derived foods. These and other carotenoids are transported into the mucosal cell by scavenger receptor class B type I (SR-BI). Provitamin A carotenoids are partly converted to retinol by oxygenase and reductase enzymes and the retinol so produced is available for absorption via the two pathways described above. The efficiency of vitamin A and carotenoid intestinal absorption is determined by the regulation of a number of proteins involved in the process. Polymorphisms in genes for these proteins lead to individual variability in the metabolism and transport of vitamin A and carotenoids. This article is part of a Special Issue entitled Retinoid and Lipid Metabolism.
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影响因子：
56.9
作者：
BLOMHOFF, R;GREEN, MH;NORUM, KR
通讯作者：
NORUM, KR
DOI：
10.1016/s0952-3278(97)90413-0
发表时间：
1997-10-01
影响因子：
3
作者：
Glatz, JFC;vanNieuwenhoven, FA;vanderVusse, GJ
通讯作者：
vanderVusse, GJ
DOI：
10.1073/pnas.79.23.7326
发表时间：
1982-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
BLOMHOFF, R;HELGERUD, P;NORUM, KR
通讯作者：
NORUM, KR
影响因子：
4.8
作者：
Davis, HR;Zhu, LJ;Altmann, SW
通讯作者：
Altmann, SW
影响因子：
4.2
作者：
During, A;Nagao, A;Terao, J
通讯作者：
Terao, J