Seroepidemiology of viral hepatitis, HIV and herpes simplex type 2 in the household population aged 21-64 years in Puerto Rico.
Seroepidemiology of viral hepatitis, HIV and herpes simplex type 2 in the household population aged 21-64 years in Puerto Rico.
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DOI：
10.1186/1471-2334-10-76
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发表时间：
2010-03-23
影响因子：
3.7
通讯作者：
Suárez E
中科院分区：
文献类型：
--
作者：
Pérez CM;Marrero E;Meléndez M;Adrovet S;Colón H;Ortiz AP;Soto-Salgado M;Albizu C;Torres EA;Suárez E
病毒性肝炎和性传播感染是关键的公共卫生问题，对一般人群的疾病传播构成巨大风险。本研究首次估计了波多黎各成人人群中HCV、HBV、HAV、HIV和HSV-2血清学标志物的流行率估计值，并评估了社会人口统计学和行为特征的变化。采用波多黎各分层整群概率抽样家庭进行血清流行病学调查。参与者完成了面对面的访谈，使用ACASI系统进行了自填式问卷调查，并提供了用于抗体检测的血液样本。病毒性肝炎、艾滋病毒和HSV-2的流行率估计数是使用逻辑回归模型估计的，该模型对每个家庭区块的参与概率和根据地理分层、家庭区块和性别分布的选择概率的倒数进行加权。共有1,654名成年人参与了这项研究。HCV血清阳性率估计值（2.3%，95% CI：1.3%-4.2%），HBV（3.1%，95% CI：2.0%-4.7%）和HSV-2（22.3%，95% CI：18.5%-26.7%）与美国人群中获得的估计值大致一致;然而，HAV在波多黎各，HIV（41.3%，95% CI：36.9%-45.8%）和HIV（1.1%，95% CI：0.5%-2.3%）血清阳性率估计值较高。不知道自己血清状况的个人比例如下：80%的HCV、98.3%的HBV、96.4%的HAV、36.4%的HIV和97.8%的HSV-2。分层后的血清阳性率估计值因人口统计学和风险相关特征而显著不同。这些数据强调了某些病毒感染对波多黎各选定人群亚组的不成比例的影响。需要在全岛作出协调一致的努力，加强病毒性肝炎和性传播感染的预防和控制战略，支持监测慢性感染，并确保对感染者进行适当的咨询、检测和医疗管理。将HCV、HBV和HSV-2咨询整合到现有的HIV预防服务中，并通过社交网络进行外展，这可能是接触高危人群的一种有价值的方法。
Viral hepatitis and sexually transmitted infections (STIs) are key public health problems that pose an enormous risk for disease transmission in the general population. This study estimated, for the first time, prevalence estimates of serologic markers of HCV, HBV, HAV, HIV and HSV-2 in the adult population of Puerto Rico and assessed variations across sociodemographic and behavioral characteristics. A seroepidemiologic survey was employed using a stratified cluster probability sample of households in Puerto Rico. Participants completed a face-to-face interview, a self-administered questionnaire using an ACASI system, and provided blood specimens for antibody testing. Prevalence estimates of viral hepatitis, HIV and HSV-2 were estimated using a logistic regression model weighting for the probability of participation in each household block and the inverse of the probability of selection according to geographic strata, households' blocks, and sex distribution. A total of 1,654 adults participated in the study. Seroprevalence estimates for HCV (2.3%, 95% CI: 1.3%-4.2%), HBV (3.1%, 95% CI: 2.0%-4.7%), and HSV-2 (22.3%, 95% CI: 18.5%-26.7%) in Puerto Rico are roughly in agreement with estimates obtained in the US population; however, HAV (41.3%, 95% CI: 36.9%-45.8%) and HIV (1.1%, 95% CI: 0.5%-2.3%) seroprevalence estimates in Puerto Rico were higher. The proportion of individuals that were unaware of their serostatus was as follows: 80% for HCV, 98.3% for HBV, 96.4% for HAV, 36.4% for HIV, and 97.8% for HSV-2. Post-stratification estimates of seroprevalence varied significantly by demographic and risk related characteristics. This data underscore the disproportionate impact of some viral infections across selected population subgroups in Puerto Rico. A concerted island-wide effort is needed to strengthen viral hepatitis and STIs prevention and control strategies, support surveillance to monitor chronic infections, and ensure appropriate counseling, testing, and medical management of infected persons. Integration of HCV, HBV, and HSV-2 counseling into HIV existing prevention services and outreach through social networks might represent a valuable approach to reach high-risk individuals.
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影响因子：
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作者：
Haley, RW;Fischer, RP
通讯作者：
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影响因子：
12.7
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